The auditory cortex is a critical structure for processing of sound information in mammals. However, as with all sensory cortices, neural activity in the auditory cortex is steered, but not deterministically controlled by sensory input, and the auditory cortex is capable of generating coordinated activity patterns even in the absence of acoustic stimulation.
The aim of this proposal is to measure and model the way sensory-evoked and internally generated information interact in the auditory cortical column. We will do this in the context of a specific hypothesis. Previous anatomical and in vitro studies of sensory cortex suggest that information from thalamus primarily follows a """"""""transcolumnar"""""""" path from layer 4, via layers 2 and 3, to layer 5;and that in layer 5 a network of large pyramidal cells is capable of generating spontaneous activity through recurrent excitation, as well as receiving """"""""feedback"""""""" input from higher cortical areas. We hypothesize that integration of sensory input with internally generated activity occurs primarily in layer 5, whereas neurons of the superficial layers are less involved in sensory-independent processing. Outputs to subcortical structures, which arise from layer 5, thus reflect the processing of sensory information in the context of the brain's internal state, whereas """"""""feedforward"""""""" corticocortical projections arising from superficial layers provide a more faithful representation of the external world to higher cortical regions. To investigate this hypothesis, we will record from neural populations across cortical layers, simultaneously with individual morphologically reconstructed neurons. We will analyze this data with a novel method called predictive dynamical modeling, in which a dynamical system model fit to spontaneous activity preceding a sensory stimulus is evaluated by its ability to predict the subsequent sensory response. We will show that a simple self-exciting system model can quantitatively predict the global dynamics of cortical networks, and further investigate how the information content of individual neurons is shaped by the interaction of global dynamics and sensory input. We will show that information is coded densely in layer 5 but sparsely in the superficial layers, consistent with a higher threshold for self-excitation in superficial layers. We will study how the laminar flow of activity changes with cortical state. The state of the cortex varies from a """"""""desynchronized"""""""" state during alert wakefulness, to a """"""""synchronized"""""""" state during drowsiness and sleep that is characterized by coordinated stimulus-independent activity. By recording across the wake-sleep cycle, we aim to show that cortical dynamics in the desynchronized state are close to linear, but become progressively more nonlinear as cortical state becomes synchronized, accompanied by a shift in the control of cortical activity from sensory input to internally generated activity. We will show that stimulus-independent activity is primarily confined to layer 5, but that in the synchronized state spontaneous patterns also reach the superficial layers, consistent with a role of this activity in replay of sensory experience. Broader Impact. Understanding the natural function of auditory cortex is critical for learning how it misfunctions in disease states. The research proposed here will require personnel with knowledge of both mathematics and biology, and interdisciplinary training will be a central part of this project. Involvement of underrepresented groups is also a priority, and our location at Rutgers Newark allows us a unique opportunity promote diverse participation in this program.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Research Project (R01)
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Special Emphasis Panel (ZRG1-IFCN-B (50))
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Platt, Christopher
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Rutgers University
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Vyazovskiy, Vladyslav V; Harris, Kenneth D (2013) Sleep and the single neuron: the role of global slow oscillations in individual cell rest. Nat Rev Neurosci 14:443-51
Yger, Pierre; Harris, Kenneth D (2013) The Convallis rule for unsupervised learning in cortical networks. PLoS Comput Biol 9:e1003272
Luczak, Artur; Bartho, Peter; Harris, Kenneth D (2013) Gating of sensory input by spontaneous cortical activity. J Neurosci 33:1684-95
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Sakata, Shuzo; Harris, Kenneth D (2012) Laminar-dependent effects of cortical state on auditory cortical spontaneous activity. Front Neural Circuits 6:109
Harris, Kenneth D (2012) Cell assemblies of the superficial cortex. Neuron 76:263-5
Okun, Michael; Yger, Pierre; Marguet, Stephan L et al. (2012) Population rate dynamics and multineuron firing patterns in sensory cortex. J Neurosci 32:17108-19
Itskov, Vladimir; Curto, Carina; Pastalkova, Eva et al. (2011) Cell assembly sequences arising from spike threshold adaptation keep track of time in the hippocampus. J Neurosci 31:2828-34

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