The long-term objective of our research is to increase the benefit that hearing impaired patients receive from their cochlear implant auditory prostheses. The approach is to improve the custom-fitting strategy by which the auditory prosthesis speech processor is adjusted to meet the characteristics of the individual patient. To do this, we need to understand the root causes of performance deficits. In our preliminary studies we have shown that most subjects can discriminate the fundamental spatial and temporal features of prosthetic stimulation needed for speech recognition, but that the ability to discriminate these features depends on the parameters of stimulation, including the location of the stimulating electrodes within their electrode array and input-output function as reflected in loudness growth. Performance varies from one stimulation site to another within an individual's cochlear implant and the pattern of this variation across stimulation sites is patient specific. These results suggest two strategies for optimizing patient performance. One strategy is to create a processor map that utilizes only those stimulation sites where performance on basic perceptual tasks is best. In support of this approach, previous studies have shown that patients tolerate a reduction in the number of stimulation sites well and that there is sometimes an improvement in performance when sites where perception is poor are removed from the processor map. A second strategy is to individually optimize the stimulation parameters on a site-by-site basis. It is known for example that stimulus level can be adjusted to improve temporal acuity. Implementation of these two strategies requires a better understanding of the basic principles underlying across-site patterns of perception in cochlear implants. Specifically, the following questions must be addressed. (1) To what extent are across-site patterns of perception similar for all perceptual measures? For example, do the underlying conditions that cause poor temporal perception also affect spatial resolution? (2) What are the relative contributions of the various psychophysical acuities to speech recognition? For example, would it be better to enhance temporal acuity at the expense, if necessary, of spatial acuity? (3) Do spatial and temporal acuity show similar dependency on stimulus level? These issues will be addressed using psychophysical and speech recognition studies in implanted human subjects. The work will deepen our understanding of the mechanisms underlying across-subject variation in speech recognition performance with cochlear implants and serve as a guide for establishing and testing clinical procedures to improve performance in individual patients.

Public Health Relevance

Cochlear implant auditory prostheses have been remarkably successful in restoring communication abilities to deaf people and people with severe hearing loss, but there is still large variability in performance among patients using the same implants and processing strategies. Our preliminary studies show that perception with the implant varies from one stimulation site to the next within a patient's multichannel implant so that each individual has strengths and weaknesses. The research proposed in this application will help elucidate some basic characteristic of the across-site patterns of performance and then define and test clinical fitting strategies that will exploit the strengths and potentially improve prosthetic hearing in thousands of individual patients.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC010786-04
Application #
8438470
Study Section
Auditory System Study Section (AUD)
Program Officer
Donahue, Amy
Project Start
2010-04-05
Project End
2015-03-31
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
4
Fiscal Year
2013
Total Cost
$301,916
Indirect Cost
$106,501
Name
University of Michigan Ann Arbor
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Schvartz-Leyzac, Kara C; Pfingst, Bryan E (2016) Across-site patterns of electrically evoked compound action potential amplitude-growth functions in multichannel cochlear implant recipients and the effects of the interphase gap. Hear Res 341:50-65
Zhou, Ning; Pfingst, Bryan E (2016) Evaluating multipulse integration as a neural-health correlate in human cochlear-implant users: Relationship to forward-masking recovery. J Acoust Soc Am 139:EL70-5
Zhou, Ning; Kraft, Casey T; Colesa, Deborah J et al. (2015) Integration of Pulse Trains in Humans and Guinea Pigs with Cochlear Implants. J Assoc Res Otolaryngol 16:523-34
Pfingst, Bryan E; Zhou, Ning; Colesa, Deborah J et al. (2015) Importance of cochlear health for implant function. Hear Res 322:77-88
Zhou, Ning; Pfingst, Bryan E (2014) Relationship between multipulse integration and speech recognition with cochlear implants. J Acoust Soc Am 136:1257
Zhou, Ning; Pfingst, Bryan E (2014) Effects of site-specific level adjustments on speech recognition with cochlear implants. Ear Hear 35:30-40
Garadat, Soha N; Zwolan, Teresa A; Pfingst, Bryan E (2013) Using temporal modulation sensitivity to select stimulation sites for processor MAPs in cochlear implant listeners. Audiol Neurootol 18:247-60
Zhou, Ning; Pfingst, Bryan E (2012) Psychophysically based site selection coupled with dichotic stimulation improves speech recognition in noise with bilateral cochlear implants. J Acoust Soc Am 132:994-1008
Zhou, Ning; Xu, Li; Pfingst, Bryan E (2012) Characteristics of detection thresholds and maximum comfortable loudness levels as a function of pulse rate in human cochlear implant users. Hear Res 284:25-32
Garadat, Soha N; Zwolan, Teresa A; Pfingst, Bryan E (2012) Across-site patterns of modulation detection: relation to speech recognition. J Acoust Soc Am 131:4030-41

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