The goal of this study is to remediate word-finding problems in patients with Primary Progressive Aphasia (PPA) and to delay the further progression of word-finding impairment. The current approach is novel in that it contains a prophylaxis component in which we attempt to strengthen neural connections that remain functional, making them more resistant to degradation as the disease progresses. While the study is specific in its targeting of word-finding problems, a successful outcome would bode well for other studies aimed at prevention or reversal of declining cognitive functions in dementia. Patients with PPA whose naming of pictures has just begun to show signs of decline will receive practice with picture naming in two conditions: viewing the picture and repeating the name;and viewing the picture with its written name, plus reading and writing the name. Naming of pictures trained in each of these conditions will be compared, at three time intervals post-training, with naming of pictures tested before the study but never trained. A scene-description task containing trained items will be used to assess generalization. It is predicted that the pairing of the picture with its written name, combined with the motor task of writing the name, will result in a greater ability to name the picture at a later date than simple practice viewing the picture and repeating the name. Generalization to other exemplars and to other task situations is also predicted. In addition, we will image the brains of the patients to determine whether patterns of brain atrophy can be used to predict treatment response.

Public Health Relevance

Primary progressive aphasia is a progressive disorder of language processing. During the early stages of primary progressive aphasia, when patients are still living at home and functioning within the normal family setting, one of the greatest challenges to normal living is difficulty communicating caused in part by the inability to access the appropriate words. The successful delay or remediation of such word finding problems - the goal of the proposed study - would have significant consequences for the quality of life of patients with primary progressive aphasia, and for their families and caregivers.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC011317-04
Application #
8704313
Study Section
Language and Communication Study Section (LCOM)
Program Officer
Cooper, Judith
Project Start
2011-08-01
Project End
2016-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
4
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Georgetown University
Department
Neurology
Type
Schools of Medicine
DUNS #
City
Washington
State
DC
Country
United States
Zip Code
20057
Meyer, Aaron M; Getz, Heidi R; Brennan, David M et al. (2016) Telerehabilitation of Anomia in Primary Progressive Aphasia. Aphasiology 30:483-507
Sebastian, Rajani; Tsapkini, Kyrana; Tippett, Donna C (2016) Transcranial direct current stimulation in post stroke aphasia and primary progressive aphasia: Current knowledge and future clinical applications. NeuroRehabilitation 39:141-52
Meyer, Aaron M; Tippett, Donna C; Friedman, Rhonda B (2016) Prophylaxis and remediation of anomia in the semantic and logopenic variants of primary progressive aphasia. Neuropsychol Rehabil :1-17
Tippett, Donna C; Hillis, Argye E; Tsapkini, Kyrana (2015) Treatment of Primary Progressive Aphasia. Curr Treat Options Neurol 17:362
Meyer, Aaron M; Snider, Sarah F; Campbell, Rachael E et al. (2015) Phonological short-term memory in logopenic variant primary progressive aphasia and mild Alzheimer's disease. Cortex 71:183-9
Meyer, Aaron M; Snider, Sarah F; Eckmann, Carol B et al. (2015) Prophylactic Treatments for Anomia in the Logopenic Variant of Primary Progressive Aphasia: Cross-Language Transfer. Aphasiology 29:1062-1081
Faria, Andreia V; Oishi, Kenichi; Yoshida, Shoko et al. (2015) Content-based image retrieval for brain MRI: an image-searching engine and population-based analysis to utilize past clinical data for future diagnosis. Neuroimage Clin 7:367-76
Faria, Andreia V; Sebastian, Rajani; Newhart, Melissa et al. (2014) Longitudinal Imaging and Deterioration in Word Comprehension in Primary Progressive Aphasia: Potential Clinical Significance. Aphasiology 28:948-963
Tsapkini, Kyrana; Frangakis, Constantine; Gomez, Yessenia et al. (2014) Augmentation of spelling therapy with transcranial direct current stimulation in primary progressive aphasia: Preliminary results and challenges. Aphasiology 28:1112-1130
Djamanakova, Aigerim; Tang, Xiaoying; Li, Xin et al. (2014) Tools for multiple granularity analysis of brain MRI data for individualized image analysis. Neuroimage 101:168-76

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