The experiments proposed in the current application use well-established micro-pressure-sensor and laser Doppler vibrometer techniques to probe underlying cochlear mechanics relating to otoacoustic emissions (OAEs). This application aims to provide direct intracochlear observation in vivo to further understand the fundamental questions in OAE generation, propagation and cochlear signal processing in reverse transmission.
The first aim will explore the cochlear active process in reverse transmission and the rest of the aims will continue and extend our previous work on the generation and propagation of distortion product OAEs (DPOAEs) in the cochlea. OAEs are sounds generated within the cochlea and being detected in the ear canal, carrying the information about the mechanisms that generate and shape them, thus providing a noninvasive view into cochlear mechanics. However, how to relate OAE to cochlea mechanics is a big challenge in OAE research. In the forward direction, sound causes a traveling wave along the cochlear partition, which is boosted by the outer hair cells'activity (cochlear amplifier). However, the role of cochlear amplifier and cochlear fluid in cochlear reverse transmission is not clear. With simultaneous intracochlear (the basilar membrane velocity and intracochlear pressure) and ear canal pressure measurements, aim one studies the generation sites of OAE in the cochlea and further explore multiple tones suppression in active cochleae;
aim two is designed to quantify the traveling wave and compression wave pressures in both forward and reverse transmissions;
aim three explores the cochlear active process in reverse transmission. Thus the results will provide fundamental intracochlear observations, test the OAE generation theories and form the foundation for developing three-dimensional cochlear model. Finally, results from the current application will lead to more efficient OAE hearing screening program used in research and clinic.
Otoacoustic emissions (OAEs) have been used in research and the clinic as a noninvasive tool to probe cochlear mechanics. However, how to link the OAE to specific cochlear mechanics is still not clear. The current application uses intracochlear approaches, micro-pressure-sensor and laser interferometer techniques, to bridge OAEs to cochlear physiology. The study will provide valuable intracochlear evidence on cochlear signal processing in OAE generation and transmission, test OAE theories and lead to more effective hearing screening programs for research and clinical applications.
|Dong, Wei (2017) Simultaneous Intracochlear Pressure Measurements from Two Cochlear Locations: Propagation of Distortion Products in Gerbil. J Assoc Res Otolaryngol 18:209-225|
|Dong, Wei; Tian, Ying; Gao, Xin et al. (2017) Middle-Ear Sound Transmission Under Normal, Damaged, Repaired, and Reconstructed Conditions. Otol Neurotol 38:577-584|
|Dong, Wei; Olson, Elizabeth S (2016) Two-Tone Suppression of Simultaneous Electrical and Mechanical Responses in the Cochlea. Biophys J 111:1805-1815|
|Dong, Wei; Decraemer, Willem F; Olson, Elizabeth S (2012) Reverse transmission along the ossicular chain in gerbil. J Assoc Res Otolaryngol 13:447-59|
|Dong, Wei; Olson, Elizabeth S (2010) Local cochlear damage reduces local nonlinearity and decreases generator-type cochlear emissions while increasing reflector-type emissions. J Acoust Soc Am 127:1422-31|