The proposed studies will focus on the neural substrates of speech motor development in children. Our plan is to use a multi-modal approach that combines advanced psychophysical and neuroimaging techniques. In our work with adults, in the context of human arm movement, we have developed a powerful new technique to identify changes in brain activity that are specifically related to behavioral measures of learning We have found that changes in brain networks that occur in conjunction with motor learning can be partitioned into those that are primarily motor in nature and those that reflect the perceptual changes that occur in conjunction with motor learning. For the proposed project, we will study healthy children from ages 5 to 12 and healthy adults. We will use fMRI measures of functional connectivity to identify the brain networks that are associated with motor and perceptual changes that occur in association with speech motor learning. We will test the hypothesis that the brain networks associated with speech motor learning can be partitioned, as in limb movement, into those that are primarily associated with the changes in motor function and those involved in the perceptual and sensory aspects of speech motor learning. We propose that the sensory and motor networks active during speech motor learning may function more independently in younger children, becoming more tightly coupled as these systems mature. We will also determine how the brain activity that accompanies speech motor learning is related to the more durable changes in brain networks that are observed under-resting state conditions following training. The hypothesis is that brain activity during speech motor learning involves networks that process sensory errors and those that code predictive or feedforward adjustments associated with adaptation and learning. We will test the idea that patterns of brain activity during task based learning that are related to the these measures can be used to predict durable changes in functional connectivity that are observed after the completion of the learning task.
The goal of the proposed research is to determine the neural substrates of speech motor learning in children and their changes over development. It is striking that almost nothing is presently known about the brain bases of speech motor learning in children. We will use sophisticated experimental models of speech motor learning and have developed experimental techniques to study speech motor learning in children as young as 5 years of age. We have developed brain imaging techniques in the context of human arm movement that we will use here in the proposed research to identify changes to separate networks in the brain that are primarily dependent on motor versus sensory changes that occur in conjunction with speech motor learning. Our work will provide a neurobiological understanding of the brain networks, their organization and the developmental trajectory of speech learning. These are a necessary prerequisite for early diagnosis of speech and language disorders, innovative approaches to treatment and the tracking of important yet subtle therapy-induced changes in brain neuroplasticity.
|Bourguignon, Nicolas J; Ohashi, Hiroki; Nguyen, Don et al. (2018) The neural dynamics of competition resolution for language production in the prefrontal cortex. Hum Brain Mapp 39:1391-1402|
|Sato, Marc; Shiller, Douglas M (2018) Auditory prediction during speaking and listening. Brain Lang 187:92-103|
|Arnaud, Laureline; Gracco, Vincent; Ménard, Lucie (2018) Enhanced perception of pitch changes in speech and music in early blind adults. Neuropsychologia 117:261-270|
|Deroche, Mickael L D; Nguyen, Don L; Gracco, Vincent L (2017) Modulation of Speech Motor Learning with Transcranial Direct Current Stimulation of the Inferior Parietal Lobe. Front Integr Neurosci 11:35|
|Ito, Takayuki; Coppola, Joshua H; Ostry, David J (2016) Speech motor learning changes the neural response to both auditory and somatosensory signals. Sci Rep 6:25926|
|Mollaei, Fatemeh; Shiller, Douglas M; Baum, Shari R et al. (2016) Sensorimotor control of vocal pitch and formant frequencies in Parkinson's disease. Brain Res 1646:269-277|
|Bourguignon, Nicolas J; Baum, Shari R; Shiller, Douglas M (2016) Please say what this word is-Vowel-extrinsic normalization in the sensorimotor control of speech. J Exp Psychol Hum Percept Perform 42:1039-47|
|Brajot, François-Xavier; Shiller, Douglas M; Gracco, Vincent L (2016) Autophonic loudness perception in Parkinson's disease. J Acoust Soc Am 139:1364-71|
|Ostry, David J; Gribble, Paul L (2016) Sensory Plasticity in Human Motor Learning. Trends Neurosci 39:114-123|
|Smits-Bandstra, Sarah; Gracco, Vincent (2015) Retention of implicit sequence learning in persons who stutter and persons with Parkinson's disease. J Mot Behav 47:124-41|
Showing the most recent 10 out of 22 publications