Aphasia, an impairment in language processing, is a common disorder associated with stroke. The hallmark deficit of aphasia is the inability to name objects or people (anomia). Many patients with chronic aphasia can improve with naming therapy, but treatment is not universally effective. If the reason for differences in treatment effectiveness were better understood, an instrument could be developed to identify the patients who have the greatest potential to improve. Furthermore, a better understanding of the predictors for language recovery could provide crucial information about the mechanisms supporting brain plasticity during rehabilitation. Our group has previously demonstrated that naming improvements due to therapy are primarily associated with functional modulation of the cerebral cortex in the left hemisphere. It follows that structural damage to cortical regions in th left hemisphere is a limiting factor for recovery. Nonetheless, preservation of the cerebral cortex cannot fully predict therapy-induced recovery. Some patients with apparently intact cortical structures are not able to recruit these areas during therapy and fail to improve. This apparent inconsistency may be related to limitations in brain mapping techniques and our hitherto inability to define the extent and location of brain damage after stroke. Specifically, cortical regions may be disconnected as a result of white matter loss. Conventional assessment tools underappreciate cortical disconnection, but it likely plays an important role in naming recovery because it prevents recruitment of spared cortical areas during therapy. With new methodological improvements in brain mapping, this hypothesis can be directly tested. It is now possible to chart neural connections in the entire brain (the brain connectome) using magnetic resonance diffusion tensor imaging. For this project, we developed optimized connectome-mapping techniques to assess neural connectivity in patients with aphasia due to a previous stroke.
We aim to investigate the impacts of cortical necrosis and cortical disconnection on chronic naming impairments and treatment-induced naming recovery. This proposal leverages high-quality imaging and behavioral data from a large prospective treatment trial in aphasia to accomplish our goals in a cost-effective manner. We will assess specific regions in the left hemisphere that have been associated with lexical-semantic retrieval and phonological processing during naming. We will also create a clinical scale for the prediction of treatment outcome based on a personalized assessment of cortical damage and cortical connectivity, advocating for each patient to be treated according to their individualized brain network profile.

Public Health Relevance

The integrity of structural connectivity supporting cortical regions in the left brain hemisphere is hypothesized to enable treatment-induced naming recovery in persons with language difficulties after a stroke (aphasia). We will map whole brain connectivity (i.e., the brain connectome) to investigate the role of cortical connectivity in impairment (Aim 1) and recovery (Aim 2) in patients with aphasia undergoing treatment. This information will be used to construct personalized markers of anomia treatment outcome (Aim 3), which may serve as a guide for speech-language pathologists and neurologists when facing patient management decisions.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
1R01DC014021-01
Application #
8748269
Study Section
Special Emphasis Panel (ZRG1-BBBP-D (02))
Program Officer
Cooper, Judith
Project Start
2014-06-10
Project End
2019-05-31
Budget Start
2014-06-10
Budget End
2015-05-31
Support Year
1
Fiscal Year
2014
Total Cost
$350,388
Indirect Cost
$74,083
Name
Medical University of South Carolina
Department
Neurosciences
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
Bonilha, Leonardo; Gleichgerrcht, Ezequiel; Nesland, Travis et al. (2016) Success of Anomia Treatment in Aphasia Is Associated With Preserved Architecture of Global and Left Temporal Lobe Structural Networks. Neurorehabil Neural Repair 30:266-79
Gleichgerrcht, Ezequiel; Fridriksson, Julius; Rorden, Chris et al. (2016) Separate neural systems support representations for actions and objects during narrative speech in post-stroke aphasia. Neuroimage Clin 10:140-5
Yourganov, Grigori; Fridriksson, Julius; Rorden, Chris et al. (2016) Multivariate Connectome-Based Symptom Mapping in Post-Stroke Patients: Networks Supporting Language and Speech. J Neurosci 36:6668-79
Kocher, Madison; Gleichgerrcht, Ezequiel; Nesland, Travis et al. (2015) Individual variability in the anatomical distribution of nodes participating in rich club structural networks. Front Neural Circuits 9:16
Gleichgerrcht, Ezequiel; Fridriksson, Julius; Bonilha, Leonardo (2015) Neuroanatomical foundations of naming impairments across different neurologic conditions. Neurology 85:284-92
Lekoubou, Alain; Gleichgerrcht, Ezequiel; McGrattan, Katlyn et al. (2015) Aphasia in multilingual individuals: the importance of bedside premorbid language proficiency assessment. eNeurologicalSci 1:1-2
Gleichgerrcht, Ezequiel; Kocher, Madison; Nesland, Travis et al. (2015) Preservation of structural brain network hubs is associated with less severe post-stroke aphasia. Restor Neurol Neurosci 34:19-28
Fedorenko, Evelina; Fillmore, Paul; Smith, Kimberly et al. (2015) The superior precentral gyrus of the insula does not appear to be functionally specialized for articulation. J Neurophysiol 113:2376-82
Bonilha, Leonardo; Gleichgerrcht, Ezequiel; Fridriksson, Julius et al. (2015) Reproducibility of the Structural Brain Connectome Derived from Diffusion Tensor Imaging. PLoS One 10:e0135247
Bonilha, Leonardo; Gleichgerrcht, Ezequiel; Nesland, Travis et al. (2015) Gray matter axonal connectivity maps. Front Psychiatry 6:35

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