In the proposed continuation project a team of investigators from the State University of New York at Buffalo, Periodontal Disease Clinical Research Center, will continue to collaborate with the diabetes epidemiologists at the National Institutes of Health Southwestern Field Study Section in Phoenix, Arizona. We propose to continue studying the relationships between diabetes and periodontal disease in a well-studied, stable population of Pima Indians who suffer from a high prevalence of non-insulin dependent diabetes mellitus (NIDDM). Studies will be carried out on subjects residing on the Gila River Indian Reservation in southwest Arizona to further evaluate the incidence, prevalence, and severity of periodontal diseases and other oral conditions in diabetic and non-diabetic subjects as well as those with impaired glucose tolerance. We propose to correlate these findings with other complications of diabetes mellitus and to evaluate the microbiological and host response factors operative in diabetics as compared to non-diabetics.
The specific aims are directed to determining the contribution of diabetic complications and control, duration of diabetes, age and sex, and the relationship of the HLA locus to periodontal diseases in diabetic Pimas. We propose to carry out longitudinal studies to determine the incidence of periodontal disease in Pima Indians, and to study its relationship to diabetes and diabetic complications. We also propose to determine the relationship of periodontal disease to diabetic family history among the Pima Indians. Studies to determine the role of immunologic factors in Pima Indians with periodontal disease by evaluating the antibody-neutrophil axis will be carried out, as will evaluation of the subgingival microflora. An assessment of the efficacy of periodontal treatment and initial healing in diabetics using tetracycline, a drug with antimicrobial and anti-inflammatory effects is also proposed. A better understanding of the role of diabetes in the initiation and progression of periodontal disease, of the host-bacterial interactions occurring in diabetics, as well as the efficacy of treatment of diabetics is a long range goal of the project. In the treatment study we will also assess the effect of periodontal disease on the diabetic state. The proposal capitalizes on the initial successful studies of the oral health status of the diabetic Pimas and proposes to continue in-depth the study of two important diseases in a community with a high prevalence of both diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
2R01DE006514-04
Application #
3220029
Study Section
(SRC)
Project Start
1982-09-01
Project End
1989-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
4
Fiscal Year
1985
Total Cost
Indirect Cost
Name
State University of New York at Buffalo
Department
Type
Schools of Dentistry/Oral Hygn
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260
Shultis, Wendy A; Weil, E Jennifer; Looker, Helen C et al. (2007) Effect of periodontitis on overt nephropathy and end-stage renal disease in type 2 diabetes. Diabetes Care 30:306-11
Saremi, Aramesh; Nelson, Robert G; Tulloch-Reid, Marshall et al. (2005) Periodontal disease and mortality in type 2 diabetes. Diabetes Care 28:27-32
Taylor, G W; Loesche, W J; Terpenning, M S (2000) Impact of oral diseases on systemic health in the elderly: diabetes mellitus and aspiration pneumonia. J Public Health Dent 60:313-20
Taylor, G W; Becker, M P (1998) Increased efficiency of analyses: cumulative logistic regression vs ordinary logistic regression. Community Dent Oral Epidemiol 26:1-6
Taylor, G W; Burt, B A; Becker, M P et al. (1998) Glycemic control and alveolar bone loss progression in type 2 diabetes. Ann Periodontol 3:30-9
Taylor, G W; Burt, B A; Becker, M P et al. (1998) Non-insulin dependent diabetes mellitus and alveolar bone loss progression over 2 years. J Periodontol 69:76-83
Taylor, G W; Burt, B A; Becker, M P et al. (1996) Severe periodontitis and risk for poor glycemic control in patients with non-insulin-dependent diabetes mellitus. J Periodontol 67:1085-93
Emrich, L J; Shlossman, M; Genco, R J (1991) Periodontal disease in non-insulin-dependent diabetes mellitus. J Periodontol 62:123-31
Nelson, R G; Shlossman, M; Budding, L M et al. (1990) Periodontal disease and NIDDM in Pima Indians. Diabetes Care 13:836-40
Shlossman, M; Knowler, W C; Pettitt, D J et al. (1990) Type 2 diabetes mellitus and periodontal disease. J Am Dent Assoc 121:532-6

Showing the most recent 10 out of 11 publications