Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE010729-03
Application #
2131633
Study Section
Oral Biology and Medicine Subcommittee 1 (OBM)
Project Start
1994-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1998-03-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Biochemistry
Type
Schools of Dentistry
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Rabin, Shira D P; Flitton, Jared G; Demuth, Donald R (2009) Aggregatibacter actinomycetemcomitans cytolethal distending toxin induces apoptosis in nonproliferating macrophages by a phosphatase-independent mechanism. Infect Immun 77:3161-9
Schaeffer, Lyndsay M; Schmidt, M Lee; Demuth, Donald R (2008) Induction of Aggregatibacter actinomycetemcomitans leukotoxin expression by IS1301 and orfA. Microbiology 154:528-38
Kinane, Denis F; Demuth, Donald R; Gorr, Sven-Ulrik et al. (2007) Human variability in innate immunity. Periodontol 2000 45:14-34
Mitchell, Christine; Gao, Ling; Demuth, Donald R (2003) Positive and negative cis-acting regulatory sequences control expression of leukotoxin in Actinobacillus actinomycetemcomitans 652. Infect Immun 71:5640-9
Fong, Karen P; Gao, Ling; Demuth, Donald R (2003) luxS and arcB control aerobic growth of Actinobacillus actinomycetemcomitans under iron limitation. Infect Immun 71:298-308
Demuth, Donald R; James, Deanna; Kowashi, Yusuke et al. (2003) Interaction of Actinobacillus actinomycetemcomitans outer membrane vesicles with HL60 cells does not require leukotoxin. Cell Microbiol 5:111-21
Kato, Satsuki; Kowashi, Yusuke; Demuth, Donald R (2002) Outer membrane-like vesicles secreted by Actinobacillus actinomycetemcomitans are enriched in leukotoxin. Microb Pathog 32:1-13
Fong, K P; Chung, W O; Lamont, R J et al. (2001) Intra- and interspecies regulation of gene expression by Actinobacillus actinomycetemcomitans LuxS. Infect Immun 69:7625-34
He, T; Nishihara, T; Demuth, D R et al. (1999) A novel insertion sequence increases the expression of leukotoxicity in Actinobacillus actinomycetemcomitans clinical isolates. J Periodontol 70:1261-8
Hritz, M; Fisher, E; Demuth, D R (1996) Differential regulation of the leukotoxin operon in highly leukotoxic and minimally leukotoxic strains of Actinobacillus actinomycetemcomitans. Infect Immun 64:2724-9

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