The overall Aim of the application is to continue follow-up and evaluation of a randomly selected tri-ethnic cohort (n=1,056) in Northern Manhattan to determine and quantify the independent contribution of periodontal infections to vascular events and atherosclerosis. In the first 3 years of this study we have found that periodontal disease is cross-sectionally associated with carotid intima media thickness (IMT). We have further reported that bacteria admitted as causally related to periodontal disease are positively related to IMT, while those associated with periodontal health are unrelated. Preliminary 3-year prospective findings in the first % of the cohort also suggest that periodontal bacteria relate to progression of carotid IMT and incident vascular events, after adjustment for conventional risk factors. In view of these very promising findings, it is crucial to continue to follow the enrolled subjects to: a) verify that the trends seen in IMT progression at year 3 are not due to chance;and b) ensure adequate power to evaluate whether these changes translate into clinical events (strokes, heart attacks and vascular deaths). Through the joint efforts of our multi-disciplinary team, we will repeat at year 6 the extensive measurements of cardiovascular risk factors, including carotid IMT (using high resolution B-mode Doppler), and the extensive periodontal examination including clinical, microbiologic (species specific DMA probes), immunologic (species specific antibodies to periodontal bacteria), and inflammatory (GCF cytokine and systemic C-reactive protein and fibrinogen) parameters. All subjects will be re-interviewed every year. Those who report a change in their clinical status suggestive of an outcome event in the period preceding or following the in-person year 6 appointments will be brought in for evaluation. All deaths will be thoroughly investigated. By the completion of our application, subjects will have had 3 time points of extensive clinical, microbiologic, immunologic and ultrasonographic longitudinal evaluation (at years 0, 3, 6) with a followup of 6 years for IMT progression measurements and a median followup of 9 years (range 7-11 years) for the incidence of clinical events. This extensively studied and methodologically robust cohort provides a unique opportunity to answer the question of the contribution of chronic periodontal infections to vascular disease. The accurate determination and quantification of this potential risk is significant for public health, Dentistry and medicine.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE013094-10
Application #
7779439
Study Section
Oral, Dental and Craniofacial Sciences Study Section (ODCS)
Program Officer
Atkinson, Jane C
Project Start
2000-06-15
Project End
2012-02-28
Budget Start
2010-03-01
Budget End
2012-02-28
Support Year
10
Fiscal Year
2010
Total Cost
$1,327,242
Indirect Cost
Name
Columbia University (N.Y.)
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Ezzati, Ali; Rundek, Tatjana; Verghese, Joe et al. (2017) Transcranial Doppler and Lower Extremity Function in Older Adults: Einstein Aging Study. J Am Geriatr Soc 65:2659-2664
Lorenz, Matthias W; Abdi, Negin Ashtiani; Scheckenbach, Frank et al. (2017) Automatic identification of variables in epidemiological datasets using logic regression. BMC Med Inform Decis Mak 17:40
Garshick, Michael; Wu, Fen; Demmer, Ryan et al. (2017) The association between socioeconomic status and subclinical atherosclerosis in a rural Bangladesh population. Prev Med 102:6-11
Liao, Ximing; Norata, Giuseppe D; Polak, Joseph F et al. (2016) Normative values for carotid intima media thickness and its progression: Are they transferrable outside of their cohort of origin? Eur J Prev Cardiol 23:1165-73
Willeit, Peter; Thompson, Simon G; Agewall, Stefan et al. (2016) Inflammatory markers and extent and progression of early atherosclerosis: Meta-analysis of individual-participant-data from 20 prospective studies of the PROG-IMT collaboration. Eur J Prev Cardiol 23:194-205
Tiozzo, Eduard; Gardener, Hannah; Hudson, Barry I et al. (2016) Subfractions of High-Density Lipoprotein-Cholesterol and Carotid Intima-Media Thickness: The Northern Manhattan Study. Stroke 47:1508-13
Sacco, Ralph L (2015) Evolution from Stroke Risk Factors to Brain Health Determinants. Cerebrovasc Dis 40:102-13
Boillot, Adrien; Demmer, Ryan T; Mallat, Ziad et al. (2015) Periodontal microbiota and phospholipases: the Oral Infections and Vascular Disease Epidemiology Study (INVEST). Atherosclerosis 242:418-23
Lorenz, Matthias W; Price, Jackie F; Robertson, Christine et al. (2015) Carotid intima-media thickness progression and risk of vascular events in people with diabetes: results from the PROG-IMT collaboration. Diabetes Care 38:1921-9
Rundek, Tatjana; Gardener, Hannah; Della-Morte, David et al. (2015) The relationship between carotid intima-media thickness and carotid plaque in the Northern Manhattan Study. Atherosclerosis 241:364-70

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