The overall objective of this proposed research is to develop near-infrared imaging for the detection and diagnosis of early dental caries (dental decay). New, more sophisticated diagnostic tools are needed for the detection and characterization of caries lesions in the early stages of development. If carious lesions are detected early enough, before cavitation, then they can be arrested/remineralized by non-surgical means through fluoride therapy, anti-bacterial therapy, dietary changes, or by low intensity laser irradiation. The principal factor limiting optical transmission through the tooth i the visible range from 400-700-nm is light scattering in sound enamel and dentin. The magnitude of light scattering decreases markedly at longer wavelengths in the near infrared due to the size of the principal light scatterers in enamel. The central hypothesis of this proposal is that the near-IR (NIR) region between 1300 and 1700-nm offers the greatest potential for new optical imaging modalities due to the weak scattering and absorption in sound dental hard tissue. The overall objectives of this proposal will be achieved through the following specific aims: (1) To test the hypothesis that the maximum contrast between sound and demineralized enamel in NIR reflectance measurements lies in the wavelength regions coincident with weak light scattering in enamel and strong water absorption, (2) To test the hypothesis that NIR imaging on proximal and occlusal surfaces can used for improved assessment of caries lesions for clinical screening, (3) To test the hypothesis that a NIR imaging system can be used for improved discrimination of composite sealants and restorations from sound and demineralized tooth structure. It is likely that if these studies and future clinical trials are a success, that his novel technology for imaging dental hard tissue will be employed for the detection and monitoring of early carious lesions without the use of ionizing radiation, thereby enabling conservative non-surgical intervention and the preservation of healthy tissue structure.

Public Health Relevance

This proposed research is relevant to public health because the development of new improved imaging methods for the detection and monitoring of early carious lesions is expected to enable conservative non- surgical intervention with preservation of healthy tissue structure without the use of ionizing radiation. The proposed research is relevant to the mission of the NIDCR because it pertains to the development of new diagnostic tools for the detection and characterization of caries lesions in the early stages of development.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
2R01DE014698-08A1
Application #
8291653
Study Section
Oral, Dental and Craniofacial Sciences Study Section (ODCS)
Program Officer
Drummond, James
Project Start
2002-08-01
Project End
2017-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
8
Fiscal Year
2012
Total Cost
$372,625
Indirect Cost
$122,625
Name
University of California San Francisco
Department
Dentistry
Type
Schools of Dentistry
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Simon, Jacob C; Lucas, Seth A; Staninec, Michal et al. (2014) Transillumination and reflectance probes for in vivo near-IR imaging of dental caries. Proc SPIE Int Soc Opt Eng 8929:89290D
Logan, Cooper M; Co, Katrina U; Fried, William A et al. (2014) Multispectral Near-Infrared Imaging of Composite Restorations in Extracted Teeth. Proc SPIE Int Soc Opt Eng 8929:89290R
Lamantia, Nicole R; Tom, Henry; Chan, Kenneth H et al. (2014) High contrast optical imaging methods for image guided laser ablation of dental caries lesions. Proc SPIE Int Soc Opt Eng 8929:
Tom, Henry; Simon, Jacob C; Chan, Kenneth H et al. (2014) Near-infrared imaging of demineralization under sealants. J Biomed Opt 19:77003
Fried, William A; Simon, Jacob C; Lucas, Seth et al. (2014) Near-IR imaging of cracks in teeth. Proc SPIE Int Soc Opt Eng 8929:89290Q
Chan, Andrew C; Darling, Cynthia L; Chan, Kenneth H et al. (2014) Attenuation of near-IR light through dentin at wavelengths from 1300-1650-nm. Proc SPIE Int Soc Opt Eng 8929:89290M
Simon, Jacob C; Chan, Kenneth H; Darling, Cynthia L et al. (2014) Multispectral near-IR reflectance imaging of simulated early occlusal lesions: variation of lesion contrast with lesion depth and severity. Lasers Surg Med 46:203-15
Tom, Henry; Chan, Kenneth H; Darling, Cynthia L et al. (2014) Near-IR imaging of demineralization under sealants. Proc SPIE Int Soc Opt Eng 8929:89290S
Fried, William A; Fried, Daniel; Chan, Kenneth H et al. (2013) High contrast reflectance imaging of simulated lesions on tooth occlusal surfaces at near-IR wavelengths. Lasers Surg Med 45:533-41
Fried, William A; Fried, Daniel; Chan, Kenneth H et al. (2013) Imaging Early Demineralization on Tooth Occlusal Surfaces with a High Definition InGaAs Camera. Proc SPIE Int Soc Opt Eng 8566:

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