The overall objective of this proposed research is to develop near-infrared imaging for the detection and diagnosis of early dental caries (dental decay). New, more sophisticated diagnostic tools are needed for the detection and characterization of caries lesions in the early stages of development. If carious lesions are detected early enough, before cavitation, then they can be arrested/remineralized by non-surgical means through fluoride therapy, anti-bacterial therapy, dietary changes, or by low intensity laser irradiation. The principal factor limiting optical transmission through the tooth i the visible range from 400-700-nm is light scattering in sound enamel and dentin. The magnitude of light scattering decreases markedly at longer wavelengths in the near infrared due to the size of the principal light scatterers in enamel. The central hypothesis of this proposal is that the near-IR (NIR) region between 1300 and 1700-nm offers the greatest potential for new optical imaging modalities due to the weak scattering and absorption in sound dental hard tissue. The overall objectives of this proposal will be achieved through the following specific aims: (1) To test the hypothesis that the maximum contrast between sound and demineralized enamel in NIR reflectance measurements lies in the wavelength regions coincident with weak light scattering in enamel and strong water absorption, (2) To test the hypothesis that NIR imaging on proximal and occlusal surfaces can used for improved assessment of caries lesions for clinical screening, (3) To test the hypothesis that a NIR imaging system can be used for improved discrimination of composite sealants and restorations from sound and demineralized tooth structure. It is likely that if these studies and future clinical trials are a success, that his novel technology for imaging dental hard tissue will be employed for the detection and monitoring of early carious lesions without the use of ionizing radiation, thereby enabling conservative non-surgical intervention and the preservation of healthy tissue structure.

Public Health Relevance

This proposed research is relevant to public health because the development of new improved imaging methods for the detection and monitoring of early carious lesions is expected to enable conservative non- surgical intervention with preservation of healthy tissue structure without the use of ionizing radiation. The proposed research is relevant to the mission of the NIDCR because it pertains to the development of new diagnostic tools for the detection and characterization of caries lesions in the early stages of development.

Agency
National Institute of Health (NIH)
Type
Research Project (R01)
Project #
5R01DE014698-10
Application #
8638779
Study Section
Oral, Dental and Craniofacial Sciences Study Section (ODCS)
Program Officer
Drummond, James
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Dentistry
Type
Schools of Dentistry/Oral Hygn
DUNS #
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Tom, Henry; Chan, Kenneth H; Darling, Cynthia L et al. (2016) Near-IR image-guided laser ablation of demineralization on tooth occlusal surfaces. Lasers Surg Med 48:52-61
Lee, Robert C; Staninec, Michal; Le, Oanh et al. (2016) Infrared Methods for Assessment of the Activity of Natural Enamel Caries Lesions. IEEE J Sel Top Quantum Electron 22:
Lee, Robert C; Darling, Cynthia L; Fried, Daniel (2016) Assessment of remineralized dentin lesions with thermal and near-infrared reflectance imaging. Proc SPIE Int Soc Opt Eng 9692:
Almaz, Elias C; Simon, Jacob C; Fried, Daniel et al. (2016) Influence of stains on lesion contrast in the pits and fissures of tooth occlusal surfaces from 800-1600-nm. Proc SPIE Int Soc Opt Eng 9692:
Simon, Jacob C; Darling, Cynthia L; Fried, Daniel (2016) A system for simultaneous near-infrared reflectance and transillumination imaging of occlusal carious lesions. Proc SPIE Int Soc Opt Eng 9692:
Simon, Jacob C; A Lucas, Seth; Lee, Robert C et al. (2016) Near-infrared imaging of secondary caries lesions around composite restorations at wavelengths from 1300-1700-nm. Dent Mater 32:587-95
Tam, Wilson; Lee, Robert C; Lin, Brent et al. (2016) Assessment of simulated lesions on primary teeth with near-infrared imaging. Proc SPIE Int Soc Opt Eng 9692:
Lee, Robert C; Darling, Cynthia L; Staninec, Michal et al. (2016) Activity assessment of root caries lesions with thermal and near-IR imaging methods. J Biophotonics :
Chan, Kenneth H; Tom, Henry; Darling, Cynthia L et al. (2015) Serial removal of caries lesions from tooth occlusal surfaces using near-IR image-guided IR laser ablation. Proc SPIE Int Soc Opt Eng 9306:
Simon, Jacob C; Lucas, Seth; Lee, Robert et al. (2015) In vitro near-infrared imaging of natural secondary caries. Proc SPIE Int Soc Opt Eng 9306:

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