The overall objective of this proposed research is to develop polarization sensitive optical coherence tomography (PS-OCT) as a non-invasive optical device for the accurate and early clinical assessment of tooth demineralization and remineralization. The central hypothesis underlying this proposal is that the depth-resolved changes in the magnitude of light scattering of dental hard tissues at 1310-nm, that occur upon demineralization and remineralization, can be imaged and quantified in vivo using PS-OCT and that those changes can be correlated with the structural changes and relative mineral loss measured using polarized-light microscopy and microradiography. The overall objectives of this proposal will be achieved through the following specific aims: (1) To test the hypothesis that the lesion volume and reflectivity from that volume can be automatically assessed in simulated in vitro caries models and natural lesions on extracted teeth using a high speed PS-OCT scanning system;(2) To test the hypothesis that PS-OCT can be used to longitudinally monitor demineralization and the inhibition of demineralization by fluoride in an extended clinical study;(3) To test the hypothesis that PS-OCT can be used to detect changes in the structure and severity of existing lesions after exposure to a remineralization agent in vivo. These studies will further validate PS-OCT as a clinical tool for the accurate and early clinical assessment of tooth demineralization and remineralization. This is expected to lead to the clinical implementation of PS-OCT for the assessment and monitoring of the activity and severity of early carious lesions without the use of ionizing radiation, leading to an increased efficiency of caries clinical trials and a marked reduction in their scope and cost.

Public Health Relevance

The overall objective of this proposed research is to develop polarization sensitive optical coherence tomography (PS-OCT) as a non-invasive optical device for the accurate and early clinical assessment of tooth demineralization and remineralization. This is expected to lead to the clinical implementation of PS-OCT for the assessment and monitoring of the activity and severity of early carious lesions without the use of ionizing radiation, leading to an increased efficiency of caries clinical trials and a marked reduction in their scope and cost.

Agency
National Institute of Health (NIH)
Type
Research Project (R01)
Project #
5R01DE017869-08
Application #
8678710
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Drummond, James
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Dentistry
Type
Schools of Dentistry/Oral Hygn
DUNS #
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Chan, Kenneth H; Tom, Henry; Fried, Daniel (2014) Monitoring the inhibition of erosion by a CO2 laser with OCT. Proc SPIE Int Soc Opt Eng 8929:89290F
Kang, Hobin; Darling, Cynthia L; Fried, Daniel (2014) Enhancing the detection of hidden occlusal caries lesions with OCT using high index liquids. Proc SPIE Int Soc Opt Eng 8929:89290O
Nee, Alexander; Chan, Kenneth; Kang, Hobin et al. (2014) Longitudinal monitoring of demineralization peripheral to orthodontic brackets using cross polarization optical coherence tomography. J Dent 42:547-55
Chan, Kenneth H; Tom, Henry; Darling, Cynthia L et al. (2014) A method for monitoring enamel erosion using laser irradiated surfaces and optical coherence tomography. Lasers Surg Med 46:672-8
Tom, Henry; Simon, Jacob C; Chan, Kenneth H et al. (2014) Near-infrared imaging of demineralization under sealants. J Biomed Opt 19:77003
Simon, Jacob C; Chan, Kenneth H; Darling, Cynthia L et al. (2014) Multispectral near-IR reflectance imaging of simulated early occlusal lesions: variation of lesion contrast with lesion depth and severity. Lasers Surg Med 46:203-15
Tom, Henry; Chan, Kenneth H; Darling, Cynthia L et al. (2014) Near-IR imaging of demineralization under sealants. Proc SPIE Int Soc Opt Eng 8929:89290S
Lee, Robert C; Darling, Cynthia L; Fried, Daniel (2014) Automated detection of remineralization in simulated enamel lesions with PS-OCT. Proc SPIE Int Soc Opt Eng 8929:89290E
Kang, Hobin; Chan, Kenneth; Darling, Cynthia L et al. (2013) Monitoring the Remineralization of Early Simulated Lesions using a pH Cycling Model with CP-OCT. Proc SPIE Int Soc Opt Eng 8566:
Fried, Daniel; Staninec, Michal; Darling, Cynthia L et al. (2013) Clinical Monitoring of Early Caries Lesions using Cross Polarization Optical Coherence Tomography. Proc SPIE Int Soc Opt Eng 8566:

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