With a majority of the more than 100,000 million dental restorative treatments performed in the US each year involving the placement of resin-bonded composite materials, and the acknowledgement that a large portion of a dentist's time is consumed with revising and replacing these restorations, there is a clear need for materials with improved clinical performance. Composite restoratives not only hold an esthetic advantage over dental amalgams, but they offer a means to adhesively bond the restoration to dentin and enamel. However, due to polymerization shrinkage stresses that challenge this critical interface from the time of placement, a strong, intact margin can not currently be reliably obtained. A highly versatile technique has been developed recently for preparing nano-scale (5 - 100 nm) polymeric particles with control over branching, chemistry and reactive site placement. These reactive nanogels can be dispersed readily at high concentrations in secondary monomers, which then infiltrate and subsequently copolymerize with the prepolymer additives. This approach has provided substantial reductions in polymerization shrinkage and stress, as well as a demonstrated ability to improve the strength of a model dental resin and composite. The proposed project would extend the positive preliminary results into practical examples of highly filled, low stress, nanogel-modified composites for restorative applications while also developing new sealant materials that rely on interpenetrating polymer networks to achieve dramatically reduced levels of free monomer during placement. Bioactive sealants based on nanogels that display anti-bacterial and potentially MMP-inhibiting properties will also be developed and demonstrated. The application is constructed around three aims: i) fundamental studies of nanogel synthesis designed to produce well controlled nanogel structures with predictable properties with a primary focus on a balance between high nanogel contents in monomeric matrices with practically useful viscosities and optical properties;ii) application of nanogels in dental composites where greater than proportional reductions in stress, relative to the nanogel content, will be sought while also improving the fracture toughness of potentially bulk filling composites that combine high loading levels of both nanogel and novel surface-treated inorganic fillers;and iii) use of nanogels to create sealant materials with interpenetrating polymer networks that form with high conversion and a reduced sensitivity to oxygen inhibition, which means more stable materials with much less leachable compound release. The sealant material platform will be further extended to demonstrate the potential bioactivity of polymers with chemically integrated nanogels that convey bactericidal and MMP- inhibition properties.

Public Health Relevance

There are over 100 million dental restorations placed in the US each year and most of these are resin-bonded composite materials which provide an excellent esthetic alternative to dental amalgams but also suffer from relatively high failure/replacement rates. A generic means has been devised to significantly improve a variety of physical and mechanical properties of dental polymeric materials based on modifications to the polymer network structure. Further, the same materials-based approach will be applied to improve the overall conversion and stability of dental sealants, which are also widely used in a preventative mode. Because of the very large numbers of patients who receive sealants and composite restorations, the predicted enhanced clinical performance and long-term reliability that is anticipated to accompany the less technique-sensitive placement of these materials will generate a substantial return in terms of fewer patient visits and improved overall oral health.

National Institute of Health (NIH)
National Institute of Dental & Craniofacial Research (NIDCR)
Research Project (R01)
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Study Section
Oral, Dental and Craniofacial Sciences Study Section (ODCS)
Program Officer
Drummond, James
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University of Colorado Denver
Schools of Dentistry/Oral Hygn
United States
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Kaastrup, Kaja; Aguirre-Soto, Alan; Wang, Chen et al. (2016) UV-Vis/FT-NIR in situ monitoring of visible-light induced polymerization of PEGDA hydrogels initiated by eosin/triethanolamine/O2. Polym Chem 7:592-602
Medel, S; Bosch, P; Grabchev, I et al. (2016) Simultaneous Measurement of Fluorescence, Conversion and Physical/mechanical Properties for Monitoring Bulk and Localized Photopolymerization Reactions in Heterogeneous Systems. RSC Adv 6:41275-41286
Szczepanski, Caroline R; Stansbury, Jeffrey W (2015) Accessing photo-based morphological control in phase-separated, cross-linked networks through delayed gelation. Eur Polym J 67:314-325
Szczepanski, Caroline R; Stansbury, Jeffrey W (2015) Modification of linear prepolymers to tailor heterogeneous network formation through photo-initiated Polymerization-Induced Phase Separation. Polymer (Guildf) 70:8-18
Liu, JianCheng; Stansbury, Jeffrey W (2014) RAFT-mediated control of nanogel structure and reactivity: chemical, physical and mechanical properties of monomer-dispersed nanogel compositions. Dent Mater 30:1252-62
Chen, Cong; Liu, JianCheng; Sun, Fang et al. (2014) Tuning Surface Microstructure and Gradient Property of Polymer by Photopolymerizable Polysiloxane-modified Nanogels. RSC Adv 4:28928-28936
Szczepanski, Caroline R; Stansbury, Jeffrey W (2014) Stress reduction in phase-separated, cross-linked networks: influence of phase structure and kinetics of reaction. J Appl Polym Sci 131:
Shah, Parag K; Stansbury, Jeffrey W (2014) Role of filler and functional group conversion in the evolution of properties in polymeric dental restoratives. Dent Mater 30:586-93
Liu, Jiancheng; Rad, Ima Y; Sun, Fang et al. (2014) Photo-Reactive Nanogel as a Means to Tune Properties during Polymer Network Formation. Polym Chem 5:
Abu-elenain, Dalia A; Lewis, Steven H; Stansbury, Jeffrey W (2013) Property evolution during vitrification of dimethacrylate photopolymer networks. Dent Mater 29:1173-81

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