Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK010206-29A1S1
Application #
2136654
Study Section
General Medicine B Study Section (GMB)
Project Start
1974-09-01
Project End
1998-06-30
Budget Start
1995-09-30
Budget End
1996-06-30
Support Year
29
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Harvard University
Department
Other Basic Sciences
Type
Schools of Public Health
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Belinsky, G S; Tashjian Jr, A H (2000) Direct measurement of hormone-induced acidification in intact bone. J Bone Miner Res 15:550-6
Frolik, C A; Cain, R L; Sato, M et al. (1999) Comparison of recombinant human PTH(1-34) (LY333334) with a C-terminally substituted analog of human PTH-related protein(1-34) (RS-66271): In vitro activity and in vivo pharmacological effects in rats. J Bone Miner Res 14:163-72
Fukayama, S; Royo, M; Sugita, M et al. (1998) New insights into interactions between the human PTH/PTHrP receptor and agonist/antagonist binding. Am J Physiol 274:E297-303
Weilbaecher, K N; Hershey, C L; Takemoto, C M et al. (1998) Age-resolving osteopetrosis: a rat model implicating microphthalmia and the related transcription factor TFE3. J Exp Med 187:775-85
Barrett, M G; Belinsky, G S; Tashjian Jr, A H (1997) A new action of parathyroid hormone. receptor-mediated stimulation of extracellular acidification in human osteoblast-like SaOS-2 cells. J Biol Chem 272:26346-53
Goad, D L; Rubin, J; Wang, H et al. (1996) Enhanced expression of vascular endothelial growth factor in human SaOS-2 osteoblast-like cells and murine osteoblasts induced by insulin-like growth factor I. Endocrinology 137:2262-8
Monroe, J J; Tashjian Jr, A H (1996) Palytoxin modulates cytosolic pH in human osteoblast-like Saos-2 cells via an interaction with Na(+)-K(+)-ATPase. Am J Physiol 270:C1277-83
Monroe, J J; Tashjian Jr, A H (1996) Pretreatment with 17 beta-estradiol attenuates basal- and PTH-stimulated membrane adenylyl cyclase activity in human osteoblast-like SAOS-2 cells. Biochem Biophys Res Commun 225:320-5
Monroe, J J; Tashjian Jr, A H (1995) Actions of palytoxin on Na+ and Ca2+ homeostasis in human osteoblast-like Saos-2 cells. Am J Physiol 269:C582-9
Fukayama, S; Tashjian Jr, A H (1994) Involvement of alkaline phosphatase in the modulation of receptor signaling in osteoblasts: evidence for a difference between human parathyroid hormone-related protein and human parathyroid hormone. J Cell Physiol 158:391-7

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