Abstract

The long range goal of this research project is to better understand the regulatory events controlling somatostatin biosynthesis. This should provide us with a more complete picture of the molecular events underlining diseases such as diabetes mellitus. This proposal will specifically examine the regulation of somatostatin gene expression using the tools of biochemistry and molecular biology. Somatostatin was originally isolated from the hypothalamus on the basis of its ability to regulate growth hormone secretions from the pituitary gland. Subsequently, it was shown to inhibit both insulin and glucagon release from the pancreas. This hormone also appears to play an important regulatory role in controlling the secretory processes in the gut, kidney, exocrine pancreas, thyroid gland and central nervous system.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK018024-11
Application #
3225905
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1979-06-01
Project End
1988-05-31
Budget Start
1986-06-01
Budget End
1987-05-31
Support Year
11
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Purdue University
Department
Type
Earth Sciences/Resources
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907

  Publications

Banerjee, Sourav; Ji, Chenggong; Mayfield, Joshua E et al. (2018) Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2. Proc Natl Acad Sci U S A 115:8155-8160
Zhang, Hui; Zhu, Qinyu; Cui, Jixin et al. (2018) Structure and evolution of the Fam20 kinases. Nat Commun 9:1218
Qiu, Yimin; Poppleton, Erik; Mekkat, Arya et al. (2018) Enzymatic Phosphorylation of Ser in a Type I Collagen Peptide. Biophys J 115:2327-2335
Pollak, Adam J; Haghighi, Kobra; Kunduri, Swati et al. (2017) Phosphorylation of serine96 of histidine-rich calcium-binding protein by the Fam20C kinase functions to prevent cardiac arrhythmia. Proc Natl Acad Sci U S A 114:9098-9103
Cui, Jixin; Zhu, Qinyu; Zhang, Hui et al. (2017) Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding. Elife 6:
Nguyen, Kim B; Sreelatha, Anju; Durrant, Eric S et al. (2016) Phosphorylation of spore coat proteins by a family of atypical protein kinases. Proc Natl Acad Sci U S A 113:E3482-91
Guo, Xing; Wang, Xiaorong; Wang, Zhiping et al. (2016) Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis. Nat Cell Biol 18:202-12
Zhu, Qinyu; Venzke, David; Walimbe, Ameya S et al. (2016) Structure of protein O-mannose kinase reveals a unique active site architecture. Elife 5:
Guo, Xing; Dixon, Jack E (2016) The 26S proteasome: A cell cycle regulator regulated by cell cycle. Cell Cycle 15:875-6
He, Yantao; Guo, Xing; Yu, Zhi-Hong et al. (2015) A potent and selective inhibitor for the UBLCP1 proteasome phosphatase. Bioorg Med Chem 23:2798-809

Showing the most recent 10 out of 61 publications