Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK025759-18
Application #
2137786
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1979-07-01
Project End
1997-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
18
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Pathology
Type
Schools of Veterinary Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Hinderer, Christian; Bell, Peter; Louboutin, Jean-Pierre et al. (2015) Neonatal Systemic AAV Induces Tolerance to CNS Gene Therapy in MPS I Dogs and Nonhuman Primates. Mol Ther 23:1298-1307
Bradbury, Allison M; Gurda, Brittney L; Casal, Margret L et al. (2015) A review of gene therapy in canine and feline models of lysosomal storage disorders. Hum Gene Ther Clin Dev 26:27-37
Hinderer, Christian; Bell, Peter; Gurda, Brittney L et al. (2014) Intrathecal gene therapy corrects CNS pathology in a feline model of mucopolysaccharidosis I. Mol Ther 22:2018-27
Hinderer, Christian; Bell, Peter; Gurda, Brittney L et al. (2014) Liver-directed gene therapy corrects cardiovascular lesions in feline mucopolysaccharidosis type I. Proc Natl Acad Sci U S A 111:14894-9
Simonaro, Calogera M; Sachot, Sylvain; Ge, Yi et al. (2013) Acid ceramidase maintains the chondrogenic phenotype of expanded primary chondrocytes and improves the chondrogenic differentiation of bone marrow-derived mesenchymal stem cells. PLoS One 8:e62715
Ferla, Rita; O'Malley, Thomas; Calcedo, Roberto et al. (2013) Gene therapy for mucopolysaccharidosis type VI is effective in cats without pre-existing immunity to AAV8. Hum Gene Ther 24:163-9
Malik, Saafan Z; Lewis, Melissa; Isaacs, Alison et al. (2012) Identification of the rostral migratory stream in the canine and feline brain. PLoS One 7:e36016
Sewell, Adrian C; Haskins, Mark E; Giger, Urs (2012) Dried blood spots for the enzymatic diagnosis of lysosomal storage diseases in dogs and cats. Vet Clin Pathol 41:548-57
Ponder, Katherine P; O'Malley, Thomas M; Wang, Ping et al. (2012) Neonatal gene therapy with a gamma retroviral vector in mucopolysaccharidosis VI cats. Mol Ther 20:898-907
Sleeper, Meg; Bish, Lawrence T; Haskins, Mark et al. (2011) Status of therapeutic gene transfer to treat cardiovascular disease in dogs and cats. J Vet Cardiol 13:131-40

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