Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK028305-15S1
Application #
2659953
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1981-07-01
Project End
1998-11-30
Budget Start
1996-12-01
Budget End
1997-11-30
Support Year
15
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Barrett, Kim E; McCole, Declan F (2016) Hydrogen peroxide scavenger, catalase, alleviates ion transport dysfunction in murine colitis. Clin Exp Pharmacol Physiol 43:1097-1106
Hoda, M Raschid; Scharl, Michael; Keely, Stephen J et al. (2010) Apical leptin induces chloride secretion by intestinal epithelial cells and in a rat model of acute chemotherapy-induced colitis. Am J Physiol Gastrointest Liver Physiol 298:G714-21
McCole, D F; Barrett, K E (2009) Decoding epithelial signals: critical role for the epidermal growth factor receptor in controlling intestinal transport function. Acta Physiol (Oxf) 195:149-59
Scharl, Michael; Paul, Gisela; Weber, Achim et al. (2009) Protection of epithelial barrier function by the Crohn's disease associated gene protein tyrosine phosphatase n2. Gastroenterology 137:2030-2040.e5
Chappell, Alfred E; Bunz, Michael; Smoll, Eric et al. (2008) Hydrogen peroxide inhibits Ca2+-dependent chloride secretion across colonic epithelial cells via distinct kinase signaling pathways and ion transport proteins. FASEB J 22:2023-36
Tillinger, Wolfgang; McCole, Declan F; Keely, Stephen J et al. (2008) Hypertonic saline reduces neutrophil-epithelial interactions in vitro and gut tissue damage in a mouse model of colitis. Am J Physiol Regul Integr Comp Physiol 295:R1839-45
McCole, Declan F; Barrett, Kim E (2007) Varied role of the gut epithelium in mucosal homeostasis. Curr Opin Gastroenterol 23:647-54
McCole, Declan F; Truong, Anh; Bunz, Michael et al. (2007) Consequences of direct versus indirect activation of epidermal growth factor receptor in intestinal epithelial cells are dictated by protein-tyrosine phosphatase 1B. J Biol Chem 282:13303-15
Keely, Stephen J; Scharl, Michael M; Bertelsen, Lone S et al. (2007) Bile acid-induced secretion in polarized monolayers of T84 colonic epithelial cells: Structure-activity relationships. Am J Physiol Gastrointest Liver Physiol 292:G290-7
Chow, Jimmy Y C; Barrett, Kim E (2007) Role of protein phosphatase 2A in calcium-dependent chloride secretion by human colonic epithelial cells. Am J Physiol Cell Physiol 292:C452-9

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