Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK030297-15
Application #
2138352
Study Section
Biochemistry Study Section (BIO)
Project Start
1982-01-01
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Peng, Dungeng; Ogura, Hiroshi; Ma, Li-Hua et al. (2013) Solution NMR characterization of magnetic/electronic properties of azide and cyanide-inhibited substrate complexes of human heme oxygenase: implications for steric ligand tilt. J Inorg Biochem 121:179-86
Meitzler, Jennifer L; Hinde, Sara; Bánfi, Botond et al. (2013) Conserved cysteine residues provide a protein-protein interaction surface in dual oxidase (DUOX) proteins. J Biol Chem 288:7147-57
Varfaj, Fatbardha; Lampe, Jed N; Ortiz de Montellano, Paul R (2012) Role of cysteine residues in heme binding to human heme oxygenase-2 elucidated by two-dimensional NMR spectroscopy. J Biol Chem 287:35181-91
Nishida, Clinton R; Ortiz de Montellano, Paul R (2011) Bioactivation of antituberculosis thioamide and thiourea prodrugs by bacterial and mammalian flavin monooxygenases. Chem Biol Interact 192:21-5
Meitzler, Jennifer L; Ortiz de Montellano, Paul R (2011) Structural stability and heme binding potential of the truncated human dual oxidase 2 (DUOX2) peroxidase domain. Arch Biochem Biophys 512:197-203
Jiang, Yongying; Trnka, Michael J; Medzihradszky, Katalin F et al. (2009) Covalent heme attachment to the protein in human heme oxygenase-1 with selenocysteine replacing the His25 proximal iron ligand. J Inorg Biochem 103:316-25
Peng, Dungeng; Ogura, Hiroshi; Zhu, Wenfeng et al. (2009) Coupling of the distal hydrogen bond network to the exogenous ligand in substrate-bound, resting state human heme oxygenase. Biochemistry 48:11231-42
Evans, John P; Kandel, Sylvie; Ortiz de Montellano, Paul R (2009) Isocyanides inhibit human heme oxygenases at the verdoheme stage. Biochemistry 48:8920-8
Ogura, Hiroshi; Evans, John P; Peng, Dungeng et al. (2009) The orbital ground state of the azide-substrate complex of human heme oxygenase is an indicator of distal H-bonding: implications for the enzyme mechanism. Biochemistry 48:3127-37
Meitzler, Jennifer L; Ortiz de Montellano, Paul R (2009) Caenorhabditis elegans and human dual oxidase 1 (DUOX1) ""peroxidase"" domains: insights into heme binding and catalytic activity. J Biol Chem 284:18634-43

Showing the most recent 10 out of 66 publications