Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
7R01DK031505-06
Application #
3230124
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1988-01-01
Project End
1989-08-31
Budget Start
1988-01-01
Budget End
1988-08-31
Support Year
6
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Louisiana State University Hsc Shreveport
Department
Type
Schools of Medicine
DUNS #
City
Shreveport
State
LA
Country
United States
Zip Code
71103
Britton, R S; O'Neill, R; Bacon, B R (1991) Chronic dietary iron overload in rats results in impaired calcium sequestration by hepatic mitochondria and microsomes [corrected] Gastroenterology 101:806-11
Britton, R S; O'Neill, R; Bacon, B R (1990) Hepatic mitochondrial malondialdehyde metabolism in rats with chronic iron overload. Hepatology 11:93-7
Britton, R S; Ferrali, M; Magiera, C J et al. (1990) Increased prooxidant action of hepatic cytosolic low-molecular-weight iron in experimental iron overload. Hepatology 11:1038-43
Sharma, B K; Bacon, B R; Britton, R S et al. (1990) Prevention of hepatocyte injury and lipid peroxidation by iron chelators and alpha-tocopherol in isolated iron-loaded rat hepatocytes. Hepatology 12:31-9
Bacon, B R; Britton, R S (1990) The pathology of hepatic iron overload: a free radical--mediated process? Hepatology 11:127-37
Nichols, G M; Bacon, B R (1989) Hereditary hemochromatosis: pathogenesis and clinical features of a common disease. Am J Gastroenterol 84:851-62
Weissleder, R; Stark, D D; Engelstad, B L et al. (1989) Superparamagnetic iron oxide: pharmacokinetics and toxicity. AJR Am J Roentgenol 152:167-73
Kvietys, P R; Inauen, W; Bacon, B R et al. (1989) Xanthine oxidase-induced injury to endothelium: role of intracellular iron and hydroxyl radical. Am J Physiol 257:H1640-6
Bacon, B R; Britton, R S; O'Neill, R (1989) Effects of vitamin E deficiency on hepatic mitochondrial lipid peroxidation and oxidative metabolism in rats with chronic dietary iron overload. Hepatology 9:398-404
Bacon, B R; Britton, R S (1989) Hepatic injury in chronic iron overload. Role of lipid peroxidation. Chem Biol Interact 70:183-226

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