Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK031559-10
Application #
2138645
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1983-04-01
Project End
1997-06-30
Budget Start
1994-07-01
Budget End
1997-06-30
Support Year
10
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Boston University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Cunningham, Barbara A; Richard, Ann-Marie T; Dillon, Joseph S et al. (2003) Glucagon-like peptide 1 and fatty acids amplify pulsatile insulin secretion from perifused rat islets. Biochem J 369:173-8
Civelek, V N; Deeney, J T; Fusonie, G E et al. (1997) Oscillations in oxygen consumption by permeabilized clonal pancreatic beta-cells (HIT) incubated in an oscillatory glycolyzing muscle extract: roles of free Ca2+, substrates, and the ATP/ADP ratio. Diabetes 46:51-6
Civelek, V N; Deeney, J T; Kubik, K et al. (1996) Temporal sequence of metabolic and ionic events in glucose-stimulated clonal pancreatic beta-cells (HIT). Biochem J 315 ( Pt 3):1015-9
Civelek, V N; Deeney, J T; Shalosky, N J et al. (1996) Regulation of pancreatic beta-cell mitochondrial metabolism: influence of Ca2+, substrate and ADP. Biochem J 318 ( Pt 2):615-21
Nilsson, T; Schultz, V; Berggren, P O et al. (1996) Temporal patterns of changes in ATP/ADP ratio, glucose 6-phosphate and cytoplasmic free Ca2+ in glucose-stimulated pancreatic beta-cells. Biochem J 314 ( Pt 1):91-4
Cunningham, B A; Deeney, J T; Bliss, C R et al. (1996) Glucose-induced oscillatory insulin secretion in perifused rat pancreatic islets and clonal beta-cells (HIT). Am J Physiol 271:E702-10
Yaney, G C; Schultz, V; Cunningham, B A et al. (1995) Phosphofructokinase isozymes in pancreatic islets and clonal beta-cells (INS-1). Diabetes 44:1285-9
Hocker, C G; Epstein, I R; Kustin, K et al. (1994) Glycolytic pH oscillations in a flow reactor. Biophys Chem 51:21-35
Juntti-Berggren, L; Civelek, V N; Berggren, P O et al. (1994) Glucose-stimulated increase in cytoplasmic pH precedes increase in free Ca2+ in pancreatic beta-cells. A possible role for pyruvate. J Biol Chem 269:14391-5
Tornheim, K (1994) Kinetic applications using high substrate and competitive inhibitor concentrations to determine Ki or Km. Anal Biochem 221:53-6

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