Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK033314-12
Application #
2139020
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1983-12-01
Project End
1997-06-30
Budget Start
1995-07-01
Budget End
1997-06-30
Support Year
12
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of South Alabama
Department
Biochemistry
Type
Schools of Medicine
DUNS #
City
Mobile
State
AL
Country
United States
Zip Code
36688
Aronson Jr, N N (1999) Aspartylglycosaminuria: biochemistry and molecular biology. Biochim Biophys Acta 1455:139-54
Liu, Y; Guan, C; Aronson Jr, N N (1998) Site-directed mutagenesis of essential residues involved in the mechanism of bacterial glycosylasparaginase. J Biol Chem 273:9688-94
Aronson Jr, N N (1996) Lysosomal glycosylasparaginase: a member of a family of amidases that employ a processed N-terminal threonine, serine or cysteine as a combined base-nucleophile catalyst. Glycobiology 6:669-75
Liu, Y; Dunn, G S; Aronson Jr, N N (1996) Purification, biochemistry and molecular cloning of an insect glycosylasparaginase from Spodoptera frugiperda. Glycobiology 6:527-36
Park, H; Rossiter, M; Fensom, A H et al. (1996) Single base deletion in exon 7 of the glycosylasparaginase gene causes a mild form of aspartylglycosaminuria in a patient of Mauritian origin. J Inherit Metab Dis 19:76-83
Ahmad, W; Li, S; Chen, H et al. (1995) Lysosomal chitobiase (CTB) and the G-protein gamma 5 subunit (GNG5) genes co-localize to human chromosome 1p22. Cytogenet Cell Genet 71:44-6
Fisher, K J; Klein, M; Park, H et al. (1993) Post-translational processing and Thr-206 are required for glycosylasparaginase activity. FEBS Lett 323:271-5
Mononen, I; Fisher, K J; Kaartinen, V et al. (1993) Aspartylglycosaminuria: protein chemistry and molecular biology of the most common lysosomal storage disorder of glycoprotein degradation. FASEB J 7:1247-56
Hancock, L W; Raab, L S; Aronson Jr, N N (1993) Synthesis and processing of rat sperm-associated alpha-L-fucosidase. Biol Reprod 48:1228-38
Park, H; Vettese, M B; Fensom, A H et al. (1993) Characterization of three alleles causing aspartylglycosaminuria: two from a British family and one from an American patient. Biochem J 290 ( Pt 3):735-41

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