Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK034208-12
Application #
2139261
Study Section
General Medicine B Study Section (GMB)
Project Start
1984-07-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Telles, Connor J; Decker, Sarah E; Motley, William W et al. (2016) Functional and molecular identification of a TASK-1 potassium channel regulating chloride secretion through CFTR channels in the shark rectal gland: implications for cystic fibrosis. Am J Physiol Cell Physiol 311:C884-C894
Forrest Jr, John N (2016) THE SHARK RECTAL GLAND MODEL: A CHAMPION OF RECEPTOR MEDIATED CHLORIDE SECRETION THROUGH CFTR. Trans Am Clin Climatol Assoc 127:162-175
Schwarz, Julia S; de Jonge, Hugo R; Forrest Jr, John N (2015) Value of Organoids from Comparative Epithelia Models. Yale J Biol Med 88:367-74
Stahl, Klaus; Stahl, Maximilian; de Jonge, Hugo R et al. (2015) ANP and CNP activate CFTR expressed in Xenopus laevis oocytes by direct activation of PKA. J Recept Signal Transduct Res 35:493-504
Kelley, Catherine A; Decker, Sarah E; Silva, Patricio et al. (2014) Gastric inhibitory peptide, serotonin, and glucagon are unexpected chloride secretagogues in the rectal gland of the skate (Leucoraja erinacea). Am J Physiol Regul Integr Comp Physiol 306:R674-80
De Jonge, Hugo R; Tilly, Ben C; Hogema, Boris M et al. (2014) cGMP inhibition of type 3 phosphodiesterase is the major mechanism by which C-type natriuretic peptide activates CFTR in the shark rectal gland. Am J Physiol Cell Physiol 306:C343-53
Stahl, Maximilian; Stahl, Klaus; Brubacher, Marie B et al. (2012) Divergent CFTR orthologs respond differently to the channel inhibitors CFTRinh-172, glibenclamide, and GlyH-101. Am J Physiol Cell Physiol 302:C67-76
Ratner, Martha A; Decker, Sarah E; Aller, Stephen G et al. (2006) Mercury toxicity in the shark (Squalus acanthias) rectal gland: apical CFTR chloride channels are inhibited by mercuric chloride. J Exp Zool A Comp Exp Biol 305:259-67
Bewley, Marie S; Pena, John T G; Plesch, Florian N et al. (2006) Shark rectal gland vasoactive intestinal peptide receptor: cloning, functional expression, and regulation of CFTR chloride channels. Am J Physiol Regul Integr Comp Physiol 291:R1157-64
Weber, Gerhard J; Mehr, Ali Poyan; Sirota, Jeffrey C et al. (2006) Mercury and zinc differentially inhibit shark and human CFTR orthologues: involvement of shark cysteine 102. Am J Physiol Cell Physiol 290:C793-801

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