Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK036182-03
Application #
3234527
Study Section
(SSS)
Project Start
1985-07-01
Project End
1988-06-30
Budget Start
1987-07-01
Budget End
1988-06-30
Support Year
3
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Chen, Chun-Rong; Hamidi, Sepehr; Braley-Mullen, Helen et al. (2010) Antibodies to thyroid peroxidase arise spontaneously with age in NOD.H-2h4 mice and appear after thyroglobulin antibodies. Endocrinology 151:4583-93
McLachlan, Sandra M; Rapoport, Basil (2007) Thyroid peroxidase as an autoantigen. Thyroid 17:939-48
Guo, Jin; McLachlan, Sandra M; Rapoport, Basil (2006) Antibodies focused on the human autoantibody immunodominant region are induced by B lymphocytes that constitutively express thyroid peroxidase diverted to the major histocompatibility complex II pathway. Thyroid 16:343-9
Quaratino, Sonia; Ruf, Jean; Osman, Mohamed et al. (2005) Human autoantibodies modulate the T cell epitope repertoire but fail to unmask a pathogenic cryptic epitope. J Immunol 174:557-63
McLachlan, Sandra M; Nagayama, Yuji; Rapoport, Basil (2005) Insight into Graves' hyperthyroidism from animal models. Endocr Rev 26:800-32
Guo, Jin; McLachlan, Sandra M; Pichurin, Pavel N et al. (2005) Relationship between thyroid peroxidase T cell epitope restriction and antibody recognition of the autoantibody immunodominant region in human leukocyte antigen DR3 transgenic mice. Endocrinology 146:4961-7
Chazenbalk, G D; Pichurin, P N; Guo, J et al. (2005) Interactions between the mannose receptor and thyroid autoantigens. Clin Exp Immunol 139:216-24
McLachlan, Sandra M; Braley-Mullen, Helen; Chen, Chun-Rong et al. (2005) Dissociation between iodide-induced thyroiditis and antibody-mediated hyperthyroidism in NOD.H-2h4 mice. Endocrinology 146:294-300
Guo, Jin; Pichurin, Pavel N; Morris, John C et al. (2004) Naked deoxyribonucleic acid vaccination induces recognition of diverse thyroid peroxidase T cell epitopes. Endocrinology 145:3671-8
Latrofa, Francesco; Phillips, Martin; Rapoport, Basil et al. (2004) Human monoclonal thyroglobulin autoantibodies: epitopes and immunoglobulin genes. J Clin Endocrinol Metab 89:5116-23

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