This research proposal involves measurements of absorption and secretion by the gastrointestinal tract in human subjects. We study normal people to elucidate physiology, and patients with intestinal diseases to elucidate pathophysiology. We use intestinal intubation with a triple-lumen, nonabsorbable marker technique to measure absorption in specific segments of the intestine. We use a one-meal balance method to measure absorption of dietary constituents. We are especially interested in chronic diarrheal diseases, malabsorption syndromes, mineral and nutrient absorption and malabsorption, antidiarrheal drugs, and fecal incontinence.
Our aim i s to expand knowledge of pathophysiology and to discover better diagnostic and therapeutic methods for people who suffer from gastrointestinal diseases.
|Coates Jr, Stephen W; Hogenauer, Christoph; Santa Ana, Carol A et al. (2004) Inhibition of neutral sodium absorption by a prostaglandin analogue in patients with cystic fibrosis. Gastroenterology 127:65-72|
|Guirl, Michael J; Hogenauer, Christoph; Santa Ana, Carol A et al. (2003) Rapid intestinal transit as a primary cause of severe chronic diarrhea in patients with amyloidosis. Am J Gastroenterol 98:2219-25|
|Lorenzo-Zuniga, Vicente; Bartoli, Ramon; Planas, Ramon et al. (2003) Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats. Hepatology 37:551-7|
|Russo, Michael A; Hogenauer, Christoph; Coates Jr, Stephen W et al. (2003) Abnormal passive chloride absorption in cystic fibrosis jejunum functionally opposes the classic chloride secretory defect. J Clin Invest 112:118-25|
|Porter, Jack L; Fordtran, John S; Santa Ana, Carol A et al. (2003) Accurate enzymatic measurement of fecal bile acids in patients with malabsorption. J Lab Clin Med 141:411-8|
|Hogenauer, C; Aichbichler, B; Santa Ana, C et al. (2002) Effect of octreotide on fluid absorption and secretion by the normal human jejunum and ileum in vivo. Aliment Pharmacol Ther 16:769-77|
|Hofmann, Alan F (2002) Cholestatic liver disease: pathophysiology and therapeutic options. Liver 22 Suppl 2:14-9|
|Hagey, L R; Schteingart, C D; Ton-Nu, H-T et al. (2002) A novel primary bile acid in the Shoebill stork and herons and its phylogenetic significance. J Lipid Res 43:685-90|
|Hogenauer, C; Meyer, R L; Netto, G J et al. (2001) Malabsorption due to cholecystokinin deficiency in a patient with autoimmune polyglandular syndrome type I. N Engl J Med 344:270-4|
|Teixeira, F V; Hofmann, A F; Hagey, L R et al. (2001) Bile acid absorption after near-total proctocolectomy in dogs: ileal pouch vs. jejunal pouch-distal rectal anastomosis. J Gastrointest Surg 5:540-5|
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