The major subject of our research is chronic diarrhea, which is important for several reasons. First, the symptom is highly disabling. Second, its etiology may be hard to determine. And third, current therapies often do not bring relief. To help remedy these problems, we have established a center for the study of diarrhea and/or malabsorption syndrome. We study the physiology of absorption/secretion, the pathophysiology of diarrhea and malabsorption, and we study patients with intractable diarrhea/malabsorption. During the last 11 years we have lyophilized stool from each patient, specimens weighing kilograms are reduced to solids that can be stored in small plastic vials. When new ideas arise we can go to our stool bank and examine specimens from 100 or more patients, to test a hypothesis or to answer a question. Our research techniques includes metabolic balance methods to measure net gastrointestinal absorption or secretin of nutrients, minerals and electrolytes; or steady state intestinal perfusion which allows detailed examination of mucosal absorption or secretion rate in the jejunum, ileum and colon. Observations in patients often lead to research ideas in volunteers and vice versa. Some of our specific goals for the next five years are as follows: 1) to develop the hypothesis that inhibition of normal gastrointestinal secretions can be beneficial in the therapy of diarrhea; 2) to search for drug that inhibit active intestinal secretion of chloride, as a method for treatment of secretory diarrhea; 3) to explore the pathogenesis of idiopathic chronic diarrhea, especially in regard to ileal malabsorption of sodium chloride and bile acids; 4) to study the pathogenesis of diarrhea when it occurs as part of """"""""Gulf War Syndrome""""""""; 5) to evaluate the hypothesis that conjugated bile acid replacement therapy is beneficial to patients with Short Bowel Syndrome; 6) to develop more accurate methods for the measurement of caloric losses due to carbohydrate, fat and protein malabsorption; 7) to determine the physical factors which control fecal consistency; and 8) to determine the mechanisms by which gastrointestinal diseases result in disorders of acid-base balance and potassium depletion.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK037172-17
Application #
6476150
Study Section
General Medicine A Subcommittee 2 (GMA)
Program Officer
Hamilton, Frank A
Project Start
1985-09-01
Project End
2002-11-30
Budget Start
2001-12-01
Budget End
2002-11-30
Support Year
17
Fiscal Year
2002
Total Cost
$404,722
Indirect Cost
Name
Baylor Research Institute
Department
Type
DUNS #
096997515
City
Dallas
State
TX
Country
United States
Zip Code
75204
Coates Jr, Stephen W; Hogenauer, Christoph; Santa Ana, Carol A et al. (2004) Inhibition of neutral sodium absorption by a prostaglandin analogue in patients with cystic fibrosis. Gastroenterology 127:65-72
Guirl, Michael J; Hogenauer, Christoph; Santa Ana, Carol A et al. (2003) Rapid intestinal transit as a primary cause of severe chronic diarrhea in patients with amyloidosis. Am J Gastroenterol 98:2219-25
Lorenzo-Zuniga, Vicente; Bartoli, Ramon; Planas, Ramon et al. (2003) Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats. Hepatology 37:551-7
Russo, Michael A; Hogenauer, Christoph; Coates Jr, Stephen W et al. (2003) Abnormal passive chloride absorption in cystic fibrosis jejunum functionally opposes the classic chloride secretory defect. J Clin Invest 112:118-25
Porter, Jack L; Fordtran, John S; Santa Ana, Carol A et al. (2003) Accurate enzymatic measurement of fecal bile acids in patients with malabsorption. J Lab Clin Med 141:411-8
Hogenauer, C; Aichbichler, B; Santa Ana, C et al. (2002) Effect of octreotide on fluid absorption and secretion by the normal human jejunum and ileum in vivo. Aliment Pharmacol Ther 16:769-77
Hofmann, Alan F (2002) Cholestatic liver disease: pathophysiology and therapeutic options. Liver 22 Suppl 2:14-9
Hagey, L R; Schteingart, C D; Ton-Nu, H-T et al. (2002) A novel primary bile acid in the Shoebill stork and herons and its phylogenetic significance. J Lipid Res 43:685-90
Hogenauer, C; Meyer, R L; Netto, G J et al. (2001) Malabsorption due to cholecystokinin deficiency in a patient with autoimmune polyglandular syndrome type I. N Engl J Med 344:270-4
Teixeira, F V; Hofmann, A F; Hagey, L R et al. (2001) Bile acid absorption after near-total proctocolectomy in dogs: ileal pouch vs. jejunal pouch-distal rectal anastomosis. J Gastrointest Surg 5:540-5

Showing the most recent 10 out of 48 publications