Ruggles, Sandra Waugh; Fletterick, Robert J; Craik, Charles S (2004) Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity. J Biol Chem 279:30751-9
|
Laboissiere, Martha C A; Young, Malin M; Pinho, Rilva G et al. (2002) Computer-assisted mutagenesis of ecotin to engineer its secondary binding site for urokinase inhibition. J Biol Chem 277:26623-31
|
Wang, S X; Esmon, C T; Fletterick, R J (2001) Crystal structure of thrombin-ecotin reveals conformational changes and extended interactions. Biochemistry 40:10038-46
|
Tsu, C A; Perona, J J; Fletterick, R J et al. (1997) Structural basis for the broad substrate specificity of fiddler crab collagenolytic serine protease 1. Biochemistry 36:5393-401
|
Gillmor, S A; Craik, C S; Fletterick, R J (1997) Structural determinants of specificity in the cysteine protease cruzain. Protein Sci 6:1603-11
|
Perona, J J; Tsu, C A; Craik, C S et al. (1997) Crystal structure of an ecotin-collagenase complex suggests a model for recognition and cleavage of the collagen triple helix. Biochemistry 36:5381-92
|
Willett, W S; Brinen, L S; Fletterick, R J et al. (1996) Delocalizing trypsin specificity with metal activation. Biochemistry 35:5992-8
|
Brinen, L S; Willett, W S; Craik, C S et al. (1996) X-ray structures of a designed binding site in trypsin show metal-dependent geometry. Biochemistry 35:5999-6009
|
Willett, W S; Gillmor, S A; Perona, J J et al. (1995) Engineered metal regulation of trypsin specificity. Biochemistry 34:2172-80
|
Guo, J; Huang, W; Zhou, G W et al. (1995) Mechanistically different catalytic antibodies obtained from immunization with a single transition-state analog. Proc Natl Acad Sci U S A 92:1694-8
|
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