Abstract

The long term objective is to clarify the mode of action of water-soluble forms of vitamin A in stimulating cellular differentiation and in showing beneficial therapeutic effects on skin without toxicity.
The specific aims are: 1) To synthesize new water-soluble derivatives of retinoic acid that show promise of possessing valuable biological or therapeutic effects, 2) To study the metabolism of these compounds in vivo and in isolated tissue cells in vitro, 3) To clarify the mechanisms of their actions in cellular differentiation, and 4) To probe the mechanisms underlying the teratogenicity of some water- soluble forms and the nonteratogenicity of others. The planned studies are directly relevant to the use of retinoids as therapeutic agents in skin disorders and neoplasm and to an understanding of teratogenicity and retinoid toxicity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
2R01DK039733-07A1
Application #
2141026
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1988-03-01
Project End
1999-01-31
Budget Start
1995-02-01
Budget End
1996-01-31
Support Year
7
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Iowa State University
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
City
Ames
State
IA
Country
United States
Zip Code
50011

  Publications

Barua, Arun B; Sidell, Neil (2004) Retinoyl beta-glucuronide: a biologically active interesting retinoid. J Nutr 134:286S-289S
Barua, Arun B (2003) Absorption and conversion of a single oral dose of beta-carotene in corn oil to vitamin A in Sprague-Dawley rats with low reserve of vitamin A. Int J Vitam Nutr Res 73:267-73
Sidell, N; Pasquali, M; Malkapuram, S et al. (2003) In vitro and in vivo effects of easily administered, low-toxic retinoid and phenylacetate compounds on human neuroblastoma cells. Br J Cancer 89:412-9
Goswami, Bhabesh C; Ivanoff, Kristi D; Barua, Arun B (2003) Absorption and conversion of 11,12-(3)H-beta-carotene to vitamin A in Sprague-Dawley rats of different vitamin A status. J Nutr 133:148-53
Barua, Arun B (2003) A simple rapid method of sample preparation for LC analysis of retinoyl beta-glucuronide and retinoic acid in water-based creams. J Pharm Biomed Anal 32:563-7
Goswami, Bhabesh C; Reida, Abigail K; Ivanoff, Kristi D et al. (2003) Intestinal absorption and metabolism of retinoyl beta-glucuronide in humans, and of 15-[14C]-retinoyl beta-glucuronide in rats of different vitamin A status. J Nutr Biochem 14:703-9
Romans, David A; Barua, Arun B; Olson, James Allen (2003) Pharmacokinetics of all-trans retinoyl beta-glucuronide in rats following intraperitoneal and oral administration. Int J Vitam Nutr Res 73:251-7
Ueltschy, Amanda; Gunning, Desiree B; Barua, Arun B et al. (2002) Effects of subcutaneously injected graded doses of all-trans retinoic acid and all-trans retinoyl beta-glucuronide on the outcome of pregnancy in Sprague-Dawley rats. Int J Vitam Nutr Res 72:229-35
Gunning, Desiree B; Barua, Arun B; Myers, Ronald K et al. (2002) Comparative histologic effects of daily topical application of creams containing all-trans-retinoic acid or all-trans-retinoyl beta-glucuronide on pig skin. Skin Pharmacol Appl Skin Physiol 15:205-12
Lin, H S; Barua, A B; Olson, J A et al. (2001) Pharmacokinetic study of all-trans-retinoyl-beta-D-glucuronide in Sprague-Dawley rats after single and multiple intravenous administration(s). J Pharm Sci 90:2023-31

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