Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK042707-07
Application #
2142486
Study Section
Neurology C Study Section (NEUC)
Project Start
1995-04-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Pathology
Type
Schools of Veterinary Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Walton, Raquel M; Wolfe, John H (2007) Abnormalities in neural progenitor cells in a dog model of lysosomal storage disease. J Neuropathol Exp Neurol 66:760-9
Watson, Deborah J; Walton, Raquel M; Magnitsky, Sergey G et al. (2006) Structure-specific patterns of neural stem cell engraftment after transplantation in the adult mouse brain. Hum Gene Ther 17:693-704
Watson, Deborah J; Passini, Marco A; Wolfe, John H (2005) Transduction of the choroid plexus and ependyma in neonatal mouse brain by vesicular stomatitis virus glycoprotein-pseudotyped lentivirus and adeno-associated virus type 5 vectors. Hum Gene Ther 16:49-56
Jiang, Kanli; Watson, Deborah J; Wolfe, John H (2005) A genetic fusion construct between the tetanus toxin C fragment and the lysosomal acid hydrolase beta-glucuronidase expresses a bifunctional protein with enhanced secretion and neuronal uptake. J Neurochem 93:1334-44
Magnitsky, S; Watson, D J; Walton, R M et al. (2005) In vivo and ex vivo MRI detection of localized and disseminated neural stem cell grafts in the mouse brain. Neuroimage 26:744-54
Watson, Deborah J; Karolewski, Brian A; Wolfe, John H (2004) Stable gene delivery to CNS cells using lentiviral vectors. Methods Mol Biol 246:413-28
Longhi, Luca; Watson, Deborah J; Saatman, Kathryn E et al. (2004) Ex vivo gene therapy using targeted engraftment of NGF-expressing human NT2N neurons attenuates cognitive deficits following traumatic brain injury in mice. J Neurotrauma 21:1723-36
Watson, Deborah J; Longhi, Luca; Lee, Edward B et al. (2003) Genetically modified NT2N human neuronal cells mediate long-term gene expression as CNS grafts in vivo and improve functional cognitive outcome following experimental traumatic brain injury. J Neuropathol Exp Neurol 62:368-80
Karolewski, Brian A; Watson, Deborah J; Parente, Michael K et al. (2003) Comparison of transfection conditions for a lentivirus vector produced in large volumes. Hum Gene Ther 14:1287-96
Watson, Deborah J; Wolfe, John H (2003) Lentiviral vectors for gene transfer to the central nervous system. Applications in lysosomal storage disease animal models. Methods Mol Med 76:383-403

Showing the most recent 10 out of 37 publications