The function of thyroid hormone receptors (TRs) as ligand dependent transcription factors is mediated by their interaction with a variety of proteins. Over the previous funding period the major focus of this project was identification and characterization of TR interacting proteins (TRIPs) and more than 20 were identified. The focus of the current period is on the mechanism of action of a subset of these TR interactors in both chromatin and non-chromatin contexts. The first specific aim is to characterize in detail the biochemical basis of the strong stimulatory effect of TRIP7, a nucleosomal protein, on TR DNA binding, and to determine functional consequences of this effect. The second specific aim is to test the hypothesis that the SWI/SNF complex is involved in the chromatin remodeling associated with activation by the TRs and, more broadly, to characterize the functional role of the SWI/SNF complex in TR action.
The third aim i s to characterize the mechanism of action of the recently identified potential co-activator TRIP4 that does not appear to act at the chromatin level.
The final aim i s to continue to maintain and develop the Thyroid hormone Receptor Resource, a web-based source of information on the TRs.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
2R01DK043382-08
Application #
2705686
Study Section
Endocrinology Study Section (END)
Program Officer
Margolis, Ronald N
Project Start
1991-08-01
Project End
2002-07-31
Budget Start
1998-09-15
Budget End
1999-07-31
Support Year
8
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
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