Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK043840-06S1
Application #
2729496
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Program Officer
Haft, Carol Renfrew
Project Start
1998-02-01
Project End
1998-06-30
Budget Start
1998-02-01
Budget End
1999-01-31
Support Year
6
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Yao, Xiaoming; Smith, Alex J; Jin, Byung-Ju et al. (2015) Aquaporin-4 regulates the velocity and frequency of cortical spreading depression in mice. Glia 63:1860-9
Sonawane, N D; Verkman, A S (2008) Thiazolidinone CFTR inhibitors with improved water solubility identified by structure-activity analysis. Bioorg Med Chem 16:8187-95
Sonawane, N D; Zegarra-Moran, Olga; Namkung, Wan et al. (2008) Alpha-aminoazaheterocyclic-methylglyoxal adducts do not inhibit cystic fibrosis transmembrane conductance regulator chloride channel activity. J Pharmacol Exp Ther 325:529-35
De La Fuente, Ricardo; Namkung, Wan; Mills, Aaron et al. (2008) Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. Mol Pharmacol 73:758-68
Sonawane, N D; Zhao, Dan; Zegarra-Moran, Olga et al. (2008) Nanomolar CFTR inhibition by pore-occluding divalent polyethylene glycol-malonic acid hydrazides. Chem Biol 15:718-28
Sonawane, N D; Zhao, Dan; Zegarra-Moran, Olga et al. (2007) Lectin conjugates as potent, nonabsorbable CFTR inhibitors for reducing intestinal fluid secretion in cholera. Gastroenterology 132:1234-44
Binder, Devin K; Yao, Xiaoming; Zador, Zsolt et al. (2006) Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels. Glia 53:631-6
Sonawane, N D; Hu, Jie; Muanprasat, Chatchai et al. (2006) Luminally active, nonabsorbable CFTR inhibitors as potential therapy to reduce intestinal fluid loss in cholera. FASEB J 20:130-2
Salinas, Danieli; Haggie, Peter M; Thiagarajah, Jay R et al. (2005) Submucosal gland dysfunction as a primary defect in cystic fibrosis. FASEB J 19:431-3
Muanprasat, Chatchai; Sonawane, N D; Salinas, Danieli et al. (2004) Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J Gen Physiol 124:125-37

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