Recent increases in childhood diabetes present an urgent public health challenge: to mount effective primary and secondary prevention efforts as soon as possible. We must therefore understand the mechanisms underlying the current epidemic, particularly the interaction of genetics with the changing epidemiology of behavioral risk factors. We propose to investigate the determinants of childhood diabetes risk in affected probands and their family members. This is a competing continuation application for the population-based Chicago Childhood Diabetes Registry. This database represents the largest number of non-Hispanic black children with diabetes worldwide, and the largest patient database for Latino children in the continental US. Ongoing ascertainment of incident cases will provide basic epidemiologic data and will anchor a further effort, in families of affected children, to describe the spectrum of youth-onset glucose intolerance in terms of inheritance and the expression of disease susceptibility alleles within families. We will specifically address these hypotheses: 1. That diabetes in youth is caused by a spectrum of etiologic processes, from the insulinopenia of autoimmune type 1 to obesity-related, insulin-resistant type 2 diabetes. A subset of children demonstrate a mixed etiology, with autoimmune beta-cell destruction aggravated by the presence of insulin resistance due to genetic susceptibility, obesity and/or physical inactivity. 2. That secular changes in the epidemiology of childhood diabetes are directly related to changes in the prevalence of both type 1 and type 2 risk factors, including obesity, physical inactivity, and perinatal exposures. 3. That familial aggregation of specific traits affects the risk of chronic complications in young people with diabetes, over and above that of glycemic control. Ultimately, this approach will permit a truly population-based molecular epidemiologic study of early-onset diabetes in families from a range of ethnic groups.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK044752-14
Application #
7059301
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Program Officer
Spain, Lisa M
Project Start
1992-09-30
Project End
2008-05-31
Budget Start
2006-06-01
Budget End
2007-05-31
Support Year
14
Fiscal Year
2006
Total Cost
$651,316
Indirect Cost
Name
University of Chicago
Department
Pediatrics
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Sobotka, Sarah A; Danielson, Kirstie K; Drum, Melinda L et al. (2014) Maternal body mass index (BMI) is independently associated with the control of diabetes mellitus in young patients. Pediatr Nurs 40:187-94
Estrada, Carmela L; Danielson, Kirstie K; Drum, Melinda L et al. (2012) Insufficient sleep in young patients with diabetes and their families. Biol Res Nurs 14:48-54
Lipton, Rebecca B; Drum, Melinda; Greeley, Siri Atma W et al. (2011) HLA-DQ haplotypes differ by ethnicity in patients with childhood-onset diabetes. Pediatr Diabetes 12:388-95
Lipton, Rebecca B; Drum, Melinda L; Danielson, Kirstie K et al. (2011) Onset features and subsequent clinical evolution of childhood diabetes over several years. Pediatr Diabetes 12:326-34
Kersey, Margaret; Lipton, Rebecca; Quinn, Michael T et al. (2010) Overweight in Latino preschoolers: do parental health beliefs matter? Am J Health Behav 34:340-8
Grigsby-Toussaint, Diana S; Lipton, Rebecca; Chavez, Noel et al. (2010) Neighborhood socioeconomic change and diabetes risk: findings from the Chicago childhood diabetes registry. Diabetes Care 33:1065-8
Danielson, Kirstie K; Drum, Melinda L; Estrada, Carmela L et al. (2010) Racial and ethnic differences in an estimated measure of insulin resistance among individuals with type 1 diabetes. Diabetes Care 33:614-9
Rosenfield, Robert L; Lipton, Rebecca B; Drum, Melinda L (2009) Thelarche, pubarche, and menarche attainment in children with normal and elevated body mass index. Pediatrics 123:84-8
Kumaraguru, Janani; Flanagan, Sarah E; Greeley, Siri Atma W et al. (2009) Tooth discoloration in patients with neonatal diabetes after transfer onto glibenclamide: a previously unreported side effect. Diabetes Care 32:1428-30
Estrada, Carmela L; Danielson, Kirstie K; Drum, Melinda L et al. (2009) Hospitalization subsequent to diagnosis in young patients with diabetes in Chicago, Illinois. Pediatrics 124:926-34

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