Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK045686-03
Application #
2144891
Study Section
Metallobiochemistry Study Section (BMT)
Project Start
1994-06-01
Project End
1997-06-30
Budget Start
1996-06-01
Budget End
1997-06-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Michigan State University
Department
Microbiology/Immun/Virology
Type
Schools of Arts and Sciences
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824
Martin-Diaconescu, Vlad; Joseph, Crisjoe A; Boer, Jodi L et al. (2017) Non-thiolate ligation of nickel by nucleotide-free UreG of Klebsiella aerogenes. J Biol Inorg Chem 22:497-503
Macomber, Lee; Minkara, Mona S; Hausinger, Robert P et al. (2015) Reduction of urease activity by interaction with the flap covering the active site. J Chem Inf Model 55:354-61
Farrugia, Mark A; Wang, Beibei; Feig, Michael et al. (2015) Mutational and Computational Evidence That a Nickel-Transfer Tunnel in UreD Is Used for Activation of Klebsiella aerogenes Urease. Biochemistry 54:6392-401
Boer, Jodi L; Mulrooney, Scott B; Hausinger, Robert P (2014) Nickel-dependent metalloenzymes. Arch Biochem Biophys 544:142-52
Farrugia, Mark A; Han, Linjie; Zhong, Yueyang et al. (2013) Analysis of a soluble (UreD:UreF:UreG)2 accessory protein complex and its interactions with Klebsiella aerogenes urease by mass spectrometry. J Am Soc Mass Spectrom 24:1328-37
Farrugia, Mark A; Macomber, Lee; Hausinger, Robert P (2013) Biosynthesis of the urease metallocenter. J Biol Chem 288:13178-85
Boer, Jodi L; Hausinger, Robert P (2012) Klebsiella aerogenes UreF: identification of the UreG binding site and role in enhancing the fidelity of urease activation. Biochemistry 51:2298-308
Carter, Eric L; Proshlyakov, Denis A; Hausinger, Robert P (2012) Apoprotein isolation and activation, and vibrational structure of the Helicobacter mustelae iron urease. J Inorg Biochem 111:195-202
Carter, Eric L; Tronrud, Dale E; Taber, Scott R et al. (2011) Iron-containing urease in a pathogenic bacterium. Proc Natl Acad Sci U S A 108:13095-9
Macomber, Lee; Hausinger, Robert P (2011) Mechanisms of nickel toxicity in microorganisms. Metallomics 3:1153-62

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