Crosstalk Between Camp and Ras in Tsh Growth Signaling

Meinkoth, Judy L.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 2R01DK045696-05
• Application #: 2144905
• Study Section: Endocrinology Study Section (END)
• Project Start: 1993-01-01
• Project End: 1999-12-31
• Budget Start: 1996-02-01
• Budget End: 1996-12-31
• Support Year: 5
• Fiscal Year: 1996

Institution

• Name: University of Pennsylvania
• Department: Pharmacology
• Type: Schools of Medicine
• DUNS #: 042250712
• City: Philadelphia
• State: PA
• Country: United States
• Zip Code: 19104

Publications

Dworet, Jessica H; Meinkoth, Judy L (2006) Interference with 3',5'-cyclic adenosine monophosphate response element binding protein stimulates apoptosis through aberrant cell cycle progression and checkpoint activation. Mol Endocrinol 20:1112-20

Santiago-Walker, Ademi E; Fikaris, Aphrothiti J; Kao, Gary D et al. (2005) Protein kinase C delta stimulates apoptosis by initiating G1 phase cell cycle progression and S phase arrest. J Biol Chem 280:32107-14

Tsygankova, Oxana M; Feshchenko, Elena; Klein, Peter S et al. (2004) Thyroid-stimulating hormone/cAMP and glycogen synthase kinase 3beta elicit opposing effects on Rap1GAP stability. J Biol Chem 279:5501-7

Lewis, Aurelia E; Fikaris, Aphrothiti J; Prendergast, Gregory V et al. (2004) Thyrotropin and serum regulate thyroid cell proliferation through differential effects on p27 expression and localization. Mol Endocrinol 18:2321-32

Tsygankova, O M; Saavedra, A; Rebhun, J F et al. (2001) Coordinated regulation of Rap1 and thyroid differentiation by cyclic AMP and protein kinase A. Mol Cell Biol 21:1921-9

Cass, L A; Meinkoth, J L (2000) Ras signaling through PI3K confers hormone-independent proliferation that is compatible with differentiation. Oncogene 19:924-32

Fernandez, N; Caloca, M J; Prendergast, G V et al. (2000) Atypical protein kinase C-zeta stimulates thyrotropin-independent proliferation in rat thyroid cells. Endocrinology 141:146-52

Tsygankova, O M; Kupperman, E; Wen, W et al. (2000) Cyclic AMP activates Ras. Oncogene 19:3609-15

Cass, L A; Summers, S A; Prendergast, G V et al. (1999) Protein kinase A-dependent and -independent signaling pathways contribute to cyclic AMP-stimulated proliferation. Mol Cell Biol 19:5882-91

Kunapuli, P; Lawson, J A; Rokach, J A et al. (1998) Prostaglandin F2alpha (PGF2alpha) and the isoprostane, 8, 12-iso-isoprostane F2alpha-III, induce cardiomyocyte hypertrophy. Differential activation of downstream signaling pathways. J Biol Chem 273:22442-52