Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK047015-03
Application #
2146329
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1994-05-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Pharmacology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Penning, Trevor M (2016) Single-molecule enzymology of steroid transforming enzymes: Transient kinetic studies and what they tell us. J Steroid Biochem Mol Biol 161:5-12
Chen, Mo; Jin, Yi; Penning, Trevor M (2015) In-Depth Dissection of the P133R Mutation in Steroid 5?-Reductase (AKR1D1): A Molecular Basis of Bile Acid Deficiency. Biochemistry 54:6343-51
Penning, Trevor M (2015) The aldo-keto reductases (AKRs): Overview. Chem Biol Interact 234:236-46
Chen, Mo; Jin, Yi; Penning, Trevor M (2015) The rate-determining steps of aldo-keto reductases (AKRs), a study on human steroid 5?-reductase (AKR1D1). Chem Biol Interact 234:360-5
Penning, Trevor M; Chen, Mo; Jin, Yi (2015) Promiscuity and diversity in 3-ketosteroid reductases. J Steroid Biochem Mol Biol 151:93-101
Chen, Mo; Penning, Trevor M (2014) 5?-Reduced steroids and human ?(4)-3-ketosteroid 5?-reductase (AKR1D1). Steroids 83:17-26
Penning, Trevor M (2014) Androgen biosynthesis in castration-resistant prostate cancer. Endocr Relat Cancer 21:T67-78
Rižner, Tea Lanišnik; Penning, Trevor M (2014) Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism. Steroids 79:49-63
Jin, Yi; Chen, Mo; Penning, Trevor M (2014) Rate of steroid double-bond reduction catalysed by the human steroid 5?-reductase (AKR1D1) is sensitive to steroid structure: implications for steroid metabolism and bile acid synthesis. Biochem J 462:163-71
Barski, Oleg A; Mindnich, Rebekka; Penning, Trevor M (2013) Alternative splicing in the aldo-keto reductase superfamily: implications for protein nomenclature. Chem Biol Interact 202:153-8

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