Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK049787-02
Application #
2150705
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1995-09-20
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Pathology
Type
Schools of Veterinary Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Jochem, Adam S; Holmes, Katie E; Stein, Timothy J (2014) c-Myc and transforming growth factor ? enhance the development of hepatic lesions due to mutant ?-catenin in transgenic mice. Comp Med 64:351-9
Figueiredo, Marxa L; Stein, Timothy J; Jochem, Adam et al. (2012) Mutant Hras(G12V) and Kras(G12D) have overlapping, but non-identical effects on hepatocyte growth and transformation frequency in transgenic mice. Liver Int 32:582-91
Stein, Timothy J; Bowden, Margaret; Sandgren, Eric P (2011) Minimal cooperation between mutant Hras and c-myc or TGF? in the regulation of mouse hepatocyte growth or transformation in vivo. Liver Int 31:1298-305
Figueiredo, Marxa L; Wentworth, Kristin M; Sandgren, Eric P (2010) Quantifying growth and transformation frequency of oncogene-expressing mouse hepatocytes in vivo. Hepatology 52:634-43
Braun, Kristin M; Thompson, Anne W; Sandgren, Eric P (2003) Hepatic microenvironment affects oval cell localization in albumin-urokinase-type plasminogen activator transgenic mice. Am J Pathol 162:195-202
Weglarz, T C; Degen, J L; Sandgren, E P (2000) Hepatocyte transplantation into diseased mouse liver. Kinetics of parenchymal repopulation and identification of the proliferative capacity of tetraploid and octaploid hepatocytes. Am J Pathol 157:1963-74
Jamal, H Z; Weglarz, T C; Sandgren, E P (2000) Cryopreserved mouse hepatocytes retain regenerative capacity in vivo. Gastroenterology 118:390-4
Braun, K M; Sandgren, E P (2000) Cellular origin of regenerating parenchyma in a mouse model of severe hepatic injury. Am J Pathol 157:561-9
Braun, K M; Degen, J L; Sandgren, E P (2000) Hepatocyte transplantation in a model of toxin-induced liver disease: variable therapeutic effect during replacement of damaged parenchyma by donor cells. Nat Med 6:320-6
Kisseberth, W C; Brettingen, N T; Lohse, J K et al. (1999) Ubiquitous expression of marker transgenes in mice and rats. Dev Biol 214:128-38

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