This is an application for a follow-up study of 50 premenopausal black and white women who will have been reduced to a post-obese state and matched by age, ethnicity and body composition with 50 never obese control women with no family history of obesity. Hypotheses are based on previous data suggesting that the component of energy expenditure most important in the etiology of obesity is activity related energy expenditure (AEE). The investigators propose that abnormal muscle energy metabolism results in low spontaneous AEE in obesity prone individuals and this in turn results in greater long-term weight gain than in the never obese controls. The investigators thus plan to follow 50 post obese and 50 never obese women for four years without intervention. These women are the participants in a previously funded project to study weight loss. At yearly intervals in the CRC the investigators will measure physical activity, body weight and composition, AEE under sedentary and free living conditions by doubly labeled water and by whole-room indirect calorimetry, oxidative capacity during treadmill exercise and by NMR during isometric exercise, oxygen costs during standardized exercise, ATP production rate in exercised muscle, exercise difficulty using measures of physiologic stress and perceived stress, fuel utilization by indirect calorimetry, and insulin sensitivity by the FSIGT.
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| Cardel, Michelle; Lemas, Dominick J; Jackson, Kristina Harris et al. (2015) Higher Intake of PUFAs Is Associated with Lower Total and Visceral Adiposity and Higher Lean Mass in a Racially Diverse Sample of Children. J Nutr 145:2146-52 |
| Hunter, Gary R; Neumeier, William H; Bickel, C Scott et al. (2014) Arterial elasticity, strength, fatigue, and endurance in older women. Biomed Res Int 2014:501754 |
| Cardel, Michelle; Willig, Amanda L; Dulin-Keita, Akilah et al. (2014) Home-schooled children are thinner, leaner, and report better diets relative to traditionally schooled children. Obesity (Silver Spring) 22:497-503 |
| Sriram, Neeraj; Hunter, Gary R; Fisher, Gordon et al. (2014) Resting energy expenditure and systolic blood pressure relationships in women across 4.5 years. J Clin Hypertens (Greenwich) 16:172-6 |
| Hunter, Gary R; Plaisance, Eric P; Fisher, Gordon (2014) Weight loss and bone mineral density. Curr Opin Endocrinol Diabetes Obes 21:358-62 |
| Kell, Kenneth P; Cardel, Michelle I; Bohan Brown, Michelle M et al. (2014) Added sugars in the diet are positively associated with diastolic blood pressure and triglycerides in children. Am J Clin Nutr 100:46-52 |
| Hamilton, Kara C; Fisher, Gordon; Roy, Jane L et al. (2013) The effects of weight loss on relative bone mineral density in premenopausal women. Obesity (Silver Spring) 21:441-8 |
| Corrick, Katie L; Hunter, Gary R; Fisher, Gordon et al. (2013) Changes in vascular hemodynamics in older women following 16 weeks of combined aerobic and resistance training. J Clin Hypertens (Greenwich) 15:241-6 |
| Hunter, Gary R; Fisher, Gordon; Bryan, David R et al. (2012) Weight loss and exercise training effect on oxygen uptake and heart rate response to locomotion. J Strength Cond Res 26:1366-73 |
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