Retinoids regulate a remarkably broad range of biological processes in both developing and adult individuals. The diversity of these effects is matched by the functional complexity of the retinoid receptors. The three types of retinoic acid receptors (RARs) and three types of retinoid X receptors (RXRs) bind at least five distinct types of retinoic acid response elements (RAREs) as either RAR/RXR heterodimers or RXR homodimers. The investigators have recently expanded the diversity of the retinoid response by identifying RIP14 as a seventh retinoid-activated receptor. We hypothesize that RIP14 plays an important, tissue-specific role in retinoid signaling and propose 4 specific aims to further characterize its activities and test this hypothesis. 1) The RIP14 gene will be isolated, and the molecular basis for the expression of the RIP14 isoforms determined. 2) RIP 14 DNA binding sites will be characterized in detail and their ability to confer response to individual isoforms will be defined. 3) The response of the PLTP gene to RIP14 will be critically tested, and other potential RIP14 targets will be identified and characterized. 4) ES cell lines defective in the RIP14 gene will be generated and used to create mice deficient in RIP14.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK053366-05
Application #
6517437
Study Section
Endocrinology Study Section (END)
Program Officer
Margolis, Ronald N
Project Start
1998-04-01
Project End
2003-03-31
Budget Start
2002-04-01
Budget End
2003-03-31
Support Year
5
Fiscal Year
2002
Total Cost
$249,744
Indirect Cost
Name
Baylor College of Medicine
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
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