The proposed Competitive Renewal is an extension of the findings of the current grant, which elucidated many new aspects of the night eating syndrome (NES). A major theme is to build upon our recent discovery of the presence of the NES among non-obese persons. There are 4 aspects of the proposal. (1) Characterization of the NES among nonobese persons. Subjects will undergo a 10-day trial during which they will record all food intake, frequent measurements of mood and hunger, and sleep patterns (monitored with sensitive actigraphs). (2) Further characterization of night eaters of normal weight by an open-label trial of sertraline that had proved effective in an open-label trial of obese night eaters. Major criteria of improvement, as in our earlier trial, will consist of: number of awakenings, number of awakenings with ingestions, percent of food intake after supper and improvement in the Clinical Global Impression of Improvement (CGI-I). (3) A double-blind, placebo-controlled trial of a larger number (n=40) of obese night eaters utilizing the same criteria of improvement. (4) Development of a cognitive behavioral treatment for the NES. Dr. Allison, a cognitive therapist who has experience with large numbers of night eaters, has documented dysfunctional thoughts relating to their night eating. She will develop a manual for the treatment of the NES in consultation with the Beck Institute and will test its efficacy.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Research Project (R01)
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Special Emphasis Panel (ZRG1-RPHB-2 (01))
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Yanovski, Susan Z
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University of Pennsylvania
Schools of Medicine
United States
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Wei, Li-Na (2012) Chromatin remodeling and epigenetic regulation of the CrabpI gene in adipocyte differentiation. Biochim Biophys Acta 1821:206-12
Allison, Kelly C; Tarves, Ellen P (2011) Treatment of night eating syndrome. Psychiatr Clin North Am 34:785-96
Allison, Kelly C; Lundgren, Jennifer D; Moore, ReneƩ H et al. (2010) Cognitive behavior therapy for night eating syndrome: a pilot study. Am J Psychother 64:91-106
Grilo, Carlos M; Crosby, Ross D; Masheb, Robin M et al. (2009) Overvaluation of shape and weight in binge eating disorder, bulimia nervosa, and sub-threshold bulimia nervosa. Behav Res Ther 47:692-6
Lundgren, J D; Amsterdam, J; Newberg, A et al. (2009) Differences in serotonin transporter binding affinity in patients with major depressive disorder and night eating syndrome. Eat Weight Disord 14:45-50
Goel, Namni; Stunkard, Albert J; Rogers, Naomi L et al. (2009) Circadian rhythm profiles in women with night eating syndrome. J Biol Rhythms 24:85-94
Lundgren, Jennifer D; Allison, Kelly C; O'Reardon, John P et al. (2008) A descriptive study of non-obese persons with night eating syndrome and a weight-matched comparison group. Eat Behav 9:343-51
Allison, Kelly C; Engel, Scott G; Crosby, Ross D et al. (2008) Evaluation of diagnostic criteria for night eating syndrome using item response theory analysis. Eat Behav 9:398-407
Boston, Raymond C; Moate, Peter J; Allison, Kelly C et al. (2008) Modeling circadian rhythms of food intake by means of parametric deconvolution: results from studies of the night eating syndrome. Am J Clin Nutr 87:1672-7
Grilo, Carlos M; Hrabosky, Joshua I; White, Marney A et al. (2008) Overvaluation of shape and weight in binge eating disorder and overweight controls: refinement of a diagnostic construct. J Abnorm Psychol 117:414-9

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