White adipose tissue (WAT) remodeling is an emerging therapeutic strategy for treatment of obesity-related disorders like diabetes. Remodeling of WAT by beta3 adrenergic activation is a robust model that allows mechanisms to be tested in vivo and in vitro. Using this model system, the progenitors of the brown adipocytes that appear in WAT were identified, and techniques for imaging, isolating, and genetically manipulating these cells in vivo were developed. These cells appear to act as adult 'remodeling stem cells'(rmSC) that are likely involved in the remodeling and cellular restoration of WAT under various conditions. This project will examine mechanisms by which these novel rmSC are recruited by WAT therapeutic remodeling and by chronic high fat feeding. The long term goal is to guide strategies for expanding metabolically desirable adipocyte phenotypes for treating obesity-related disorders.
This project will examine mechanisms by which novel adult stem cells in white adipose tissue are recruited by therapeutic remodeling and by chronic high fat feeding. The long term goal is to guide strategies for expanding metabolically desirable adipocyte phenotypes for treating obesity-related disorders.
|Lee, Yun-Hee; Mottillo, Emilio P; Granneman, James G (2014) Adipose tissue plasticity from WAT to BAT and in between. Biochim Biophys Acta 1842:358-69|
|Lee, Yun-Hee; Thacker, Robert I; Hall, Brian Eric et al. (2014) Exploring the activated adipogenic niche: interactions of macrophages and adipocyte progenitors. Cell Cycle 13:184-90|
|Contreras, G Andres; Lee, Yun-Hee; Mottillo, Emilio P et al. (2014) Inducible brown adipocytes in subcutaneous inguinal white fat: the role of continuous sympathetic stimulation. Am J Physiol Endocrinol Metab 307:E793-9|
|Muzik, Otto; Mangner, Thomas J; Leonard, William R et al. (2013) 15O PET measurement of blood flow and oxygen consumption in cold-activated human brown fat. J Nucl Med 54:523-31|
|Lee, Yun-Hee; Petkova, Anelia P; Granneman, James G (2013) Identification of an adipogenic niche for adipose tissue remodeling and restoration. Cell Metab 18:355-67|