NYU Langone Medical Center experienced an unprecedented storm on October 29th, 2012, causing damage that deeply impacted our patient care, research, and educational facilities. NYULMCs emergency power system was designed and built according to all safety codes to withstand a surge higher than the highest flood level for New York City in the past century. Superstorm Sandy obviously exceeded those levels. Although we safely evacuated over 300 patients from Tisch Hospital and Schwartz Health Care Center (HCC) in the midst of the storm, our main campus incurred extensive damage to its mechanical, electrical, and plumbing systems, requiring the temporary closure of our main campus. There are three basic science buildings, the Skirball Institute, the Smilow Research Center, and the Medical Science Building (MSB). The below-ground levels of two of these buildings, the Smilow Research Center and MSB, which included two vivarium facilities, were significantly damaged. The animal vivarium of Smilow was deemed completely unrecoverable. The MSB vivarium remains closed. While Skirball and Smilow were operational within two months post- Sandy, MSB remains closed and its phased reopening is expected to begin this summer. In addition, Bellevue Hospital, where the CTSI is located and where we conduct the evaluations that require skilled nursing assistance, was closed for over 3 months.

Public Health Relevance

Due to the rampant obesity epidemic; type 2 diabetes is also increasing at an alarming rate in the USA. Inaddition to the ill effects of diabetes on the eyes; kidneys; and limbs; there is now evidence that the brain isalso affected early in the disease. The goal of this research is to increase our understanding of how the brainis affected so as to be in a position to develop treatment strategies to try to protect the brain during diabetes.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Research Project (R01)
Project #
Application #
Study Section
Program Officer
Jones, Teresa L Z
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
New York University
Schools of Medicine
New York
United States
Zip Code
Wang, Gene-Jack; Tomasi, Dardo; Convit, Antonio et al. (2014) BMI modulates calorie-dependent dopamine changes in accumbens from glucose intake. PLoS One 9:e101585
Yau, Po Lai; Kluger, Alan; Borod, Joan C et al. (2014) Neural substrates of verbal memory impairments in adults with type 2 diabetes mellitus. J Clin Exp Neuropsychol 36:74-87
Hempel, R; Onopa, R; Convit, Antonio (2012) Type 2 diabetes affects hippocampus volume differentially in men and women. Diabetes Metab Res Rev 28:76-83
Duong, Michelle; Cohen, Jessica I; Convit, Antonio (2012) High cortisol levels are associated with low quality food choice in type 2 diabetes. Endocrine 41:76-81
Cohen, Jessica I; Cazettes, Fanny; Convit, Antonio (2011) Abnormal cholesterol is associated with prefrontal white matter abnormalities among obese adults, a diffusion tensor imaging study. Neuroradiol J 1:989-997
Cazettes, Fanny; Cohen, Jessica I; Yau, Po Lai et al. (2011) Obesity-mediated inflammation may damage the brain circuit that regulates food intake. Brain Res 1373:101-9
Hassenstab, Jason J; Sweat, Victoria; Bruehl, Hannah et al. (2010) Metabolic syndrome is associated with learning and recall impairment in middle age. Dement Geriatr Cogn Disord 29:356-62
Bruehl, H; Sweat, V; Hassenstab, J et al. (2010) Cognitive impairment in nondiabetic middle-aged and older adults is associated with insulin resistance. J Clin Exp Neuropsychol 32:487-93
Yau, Po Lai; Javier, David; Tsui, Wai et al. (2009) Emotional and neutral declarative memory impairments and associated white matter microstructural abnormalities in adults with type 2 diabetes. Psychiatry Res 174:223-30
Arentoft, Alyssa; Sweat, Victoria; Starr, Vanessa et al. (2009) Plasma BDNF is reduced among middle-aged and elderly women with impaired insulin function: evidence of a compensatory mechanism. Brain Cogn 71:147-52

Showing the most recent 10 out of 18 publications