Chronic kidney disease (CKD) afflicts 11% of the adult US population. Susceptibility to CKD varies considerably, suggesting a role for genetic factors. Knowledge of genetic predictors of CKD may lead to better methods of identifying and treating individuals at risk to prevent the rising incidence and prevalence of endstage renal disease. The Genetic Epidemiology Network of Arteriopathy (GENOA) has conducted genomewide linkage and association studies to identify genes influencing blood pressure and the arteriosclerotic cerebral, cardiac, and peripheral vascular complications of hypertension. The proposed investigation will extend those efforts by identifying genetic predictors of CKD in previously well-characterized European-white and African- American sibships with 2 or more hypertensive members. We propose to identify genetic predictors of CKD in these ethnically diverse, high-risk cohorts by accomplishing the following specific aims:
Aim 1 : Determine whether conventional or novel risk factors for arteriosclerosis (already measured by GENOA) predict glomerular filtration rate or albuminuria in 1000 European-white and 1000 African-American siblings.
Aim 2 : Determine whether diallelic polymorphisms in >250 candidate genes for hypertension or its arteriosclerotic cerebral, cardiac, and peripheral vascular vascular complications (already measured by GENOA) predict glomerular filtration rate or albuminuria in 1000 European-white and 1000 African-American siblings.
Aim 3 : Determine whether any of 387 highly polymorphic tandem repeat marker loci spanning the genome (already measured by GENOA) are linked to genes influencing glomerular filtration rate or albuminuria in more than 1000 European-white and 1000 African-American sibling pairs. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
1R01DK073537-01
Application #
7019574
Study Section
Special Emphasis Panel (ZRG1-HOP-N (90))
Program Officer
Rasooly, Rebekah S
Project Start
2006-02-20
Project End
2011-01-31
Budget Start
2006-02-20
Budget End
2007-01-31
Support Year
1
Fiscal Year
2006
Total Cost
$521,361
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Pottel, Hans; Delanaye, Pierre; Schaeffner, Elke et al. (2017) Estimating glomerular filtration rate for the full age spectrum from serum creatinine and cystatin C. Nephrol Dial Transplant 32:497-507
Canales, Benjamin K; Smith, Jennifer A; Weiner, I David et al. (2017) Polymorphisms in Renal Ammonia Metabolism Genes Correlate With 24-Hour Urine pH. Kidney Int Rep 2:1111-1121
Pottel, Hans; Hoste, Liesbeth; Dubourg, Laurence et al. (2016) An estimated glomerular filtration rate equation for the full age spectrum. Nephrol Dial Transplant 31:798-806
Lieske, John C; Turner, Stephen T; Edeh, Samuel N et al. (2016) Heritability of dietary traits that contribute to nephrolithiasis in a cohort of adult sibships. J Nephrol 29:45-51
Perinpam, Majuran; Ware, Erin B; Smith, Jennifer A et al. (2015) Effect of Demographics on Excretion of Key Urinary Factors Related to Kidney Stone Risk. Urology 86:690-6
Hickson, LaTonya J; Rule, Andrew D; Butler Jr, Kenneth R et al. (2015) Troponin T as a Predictor of End-Stage Renal Disease and All-Cause Death in African Americans and Whites From Hypertensive Families. Mayo Clin Proc 90:1482-91
Ware, Erin B; Riehle, Ellen; Smith, Jennifer A et al. (2015) SLC2A9 Genotype Is Associated with SLC2A9 Gene Expression and Urinary Uric Acid Concentration. PLoS One 10:e0128593
Holliday, Elizabeth G; Traylor, Matthew; Malik, Rainer et al. (2014) Polygenic overlap between kidney function and large artery atherosclerotic stroke. Stroke 45:3508-13
Lieske, John C; Turner, Stephen T; Edeh, Samuel N et al. (2014) Heritability of urinary traits that contribute to nephrolithiasis. Clin J Am Soc Nephrol 9:943-50
Rule, Andrew D; Bailey, Kent R; Lieske, John C et al. (2013) Estimating the glomerular filtration rate from serum creatinine is better than from cystatin C for evaluating risk factors associated with chronic kidney disease. Kidney Int 83:1169-76

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