A remarkable feature of the vertebrate liver is its ability to regenerate following injury. Multiple parallel pathways feed into the regenerative response. We believe that unlocking the systems that control the regenerative response will lead to treatments for liver diseases. We are focusing upon the tumor necrosis factor (TNF) superfamily which is a large group of ligands and receptors with diverse biologic activities. Our laboratory is uncovering the exact intra- and extrahepatocellular events of the TNF related member, lymphotoxin. Specifically, we are examining the mechanisms by which this potent molecule contributes to liver regeneration. We are focusing upon the interactions between the lymphotoxin receptor on hepatocytes and lymphotoxin expressed on immune cells. First, we aim to show what cell survival mechanisms the lymphotoxin beta receptor triggers. Second, we link the production of interleukin 6 and stimulation of STAT3 phosphorylation to the lymphotoxin receptor. Third, we specifically tie the lymphotoxin receptor to the production of IL-6 and the intrahepatic cellular response. Together these aims will define the role of TNF superfamily member in liver regeneration and lead to a better understanding of what causes and could potentially prevent liver injury.
Liver diseases are among the leading causes of death for Americans and few treatments options exist. Our laboratory seeks to understand how the liver responds to injuries. What we discover is relevant to livers diseases such as viral and non-viral hepatitis, chronic liver disease and liver cancer.
|Guo, Xiaohuan; Liang, Yong; Zhang, Yuan et al. (2015) Innate Lymphoid Cells Control Early Colonization Resistance against Intestinal Pathogens through ID2-Dependent Regulation of the Microbiota. Immunity 42:731-43|
|Nguyen, Quy; Anders, Robert A; Alpini, Gianfranco et al. (2015) Yes-associated protein in the liver: Regulation of hepatic development, repair, cell fate determination and tumorigenesis. Dig Liver Dis 47:826-35|
|Hu, Bo; Sun, Ding; Sun, Chao et al. (2015) A polymeric nanoparticle formulation of curcumin in combination with sorafenib synergistically inhibits tumor growth and metastasis in an orthotopic model of human hepatocellular carcinoma. Biochem Biophys Res Commun 468:525-32|
|Guo, Xiaohuan; Qiu, Ju; Tu, Tony et al. (2014) Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection. Immunity 40:25-39|
|Gurda, Grzegorz T; Zhu, Qingfeng; Bai, Haibo et al. (2014) The use of Yes-associated protein expression in the diagnosis of persistent neonatal cholestatic liver disease. Hum Pathol 45:1057-64|
|Upadhyay, Vaibhav; Fu, Yang-Xin (2014) Lymphotoxin organizes contributions to host defense and metabolic illness from innate lymphoid cells. Cytokine Growth Factor Rev 25:227-33|
|Yang, Xuanming; Zhang, Xunmin; Sun, Yonglian et al. (2014) A BTLA-mediated bait and switch strategy permits Listeria expansion in CD8Î±(+) DCs to promote long-term T cell responses. Cell Host Microbe 16:68-80|
|Sauter, Jennifer L; Nayar, Suresh K; Anders, Paige D et al. (2013) Co-existence of Sarcina Organisms and Helicobacter pylori Gastritis/Duodenitis in Pediatric Siblings. J Clin Anat Pathol (JCAP) 1:|
|Sun, Hai-Xiang; Xu, Yang; Yang, Xin-Rong et al. (2013) Hypoxia inducible factor 2 alpha inhibits hepatocellular carcinoma growth through the transcription factor dimerization partner 3/ E2F transcription factor 1-dependent apoptotic pathway. Hepatology 57:1088-97|
|Upadhyay, Vaibhav; Fu, Yang-Xin (2013) Lymphotoxin signalling in immune homeostasis and the control of microorganisms. Nat Rev Immunol 13:270-9|
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