Lupus is a systemic autoimmune disease that is complex in genetics and its immunological origins. Renal disease is a leading cause of morbidity and mortality in lupus, particularly among minority women. Although serial renal biopsies may be ideal in closely monitoring the progression of lupus nephritis, it may not be practical or feasible. Hence, the long-term goal of these studies is to identify potential biomarkers that may be of use in monitoring the progression of renal disease in lupus. Using different proteomic approaches, we have uncovered several molecules that appear in the urine during antibody-mediated nephritis. Our completed cross-sectional studies have helped uncover 6 potential biomarker candidates in the urine of mice and patients with lupus. In this proposal, we will study a cohort of lupus patients, 90% of whom are minority individuals, in a longitudinal fashion in order to determine if any of the urinary biomarker candidates might be better at predicting flares, severe histological nephritis, or end stage renal disease, compared to currently used laboratory yardsticks. In addition, we propose to establish the specificity of these biomarkers for lupus nephritis, as well as other causes of proteinuria and nephritis. Given the high incidence of end stage renal disease in lupus, early diagnosis and prompt treatment is absolutely essential. Identification of more predictive biomarkers in the urine of these patients could have a profound impact on the clinical management of lupus nephritis.
Given the high incidence of end stage renal disease in minority women with lupus, early diagnosis and prompt treatment is absolutely essential. Identification of surrogate biomarkers in the urine of these patients could have a profound impact on the clinical management of lupus nephritis. Finally, establishing the pathogenic roles of some of these biomarkers, may pave the way towards better therapy for this disease.
|Mok, Chi Chiu; Soliman, Samar; Ho, Ling Yin et al. (2018) Urinary angiostatin, CXCL4 and VCAM-1 as biomarkers of lupus nephritis. Arthritis Res Ther 20:6|
|Selvam, Anjan Panneer; Wangzhou, Andi; Jacobs, Michael et al. (2017) Development and validation of an impedance biosensor for point-of-care detection of vascular cell adhesion molecule-1 toward lupus diagnostics. Future Sci OA 3:FSO224|
|Parodis, I; Ding, H; Zickert, A et al. (2016) Serum soluble tumour necrosis factor receptor-2 (sTNFR2) as a biomarker of kidney tissue damage and long-term renal outcome in lupus nephritis. Scand J Rheumatol :1-10|
|Du, Yong; Liu, Chih-Hao; Lei, Ling et al. (2016) Rapid, noninvasive quantitation of skin disease in systemic sclerosis using optical coherence elastography. J Biomed Opt 21:46002|
|Liu, Chih-Hao; Du, Yong; Singh, Manmohan et al. (2016) Classifying murine glomerulonephritis using optical coherence tomography and optical coherence elastography. J Biophotonics 9:781-91|
|Mok, Chi Chiu; Ding, Hui Hua; Kharboutli, Marwa et al. (2016) Axl, Ferritin, Insulin-Like Growth Factor Binding Protein 2, and Tumor Necrosis Factor Receptor Type II as Biomarkers in Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken) 68:1303-9|
|Orme, Jacob J; Du, Yong; Vanarsa, Kamala et al. (2016) Heightened cleavage of Axl receptor tyrosine kinase by ADAM metalloproteases may contribute to disease pathogenesis in SLE. Clin Immunol 169:58-68|
|Wu, Tianfu; Ding, Huihua; Han, Jie et al. (2016) Antibody-Array-Based Proteomic Screening of Serum Markers in Systemic Lupus Erythematosus: A Discovery Study. J Proteome Res 15:2102-14|
|Wu, Tianfu; Xie, Chun; Han, Jie et al. (2016) Insulin-Like Growth Factor Binding Protein-4 as a Marker of Chronic Lupus Nephritis. PLoS One 11:e0151491|
|Du, Yong; Wu, Tianfu; Zhou, Xin J et al. (2016) Blockade of CD354 (TREM-1) Ameliorates Anti-GBM-Induced Nephritis. Inflammation 39:1169-76|
Showing the most recent 10 out of 28 publications