A major risk factor for common diseases n the African American population is obesity, which occurs in 45% of the adult population. To date little is known about the genetic contributors to adiposity and obesity in this population. We have performed a genome-wide association study (GWAS) on body mass index (BMI) in 1760 African Americans derived from a type 2 diabetes (T2DM) study R01 DK663581 "Genetics of African American Type 2 Diabetes". Our initial GWAS results suggest that genetic factors affecting adiposity in African Americans appear to be largely different from those previously identified in European-derived populations. Thus, identification of genetic loci affecting adiposity and obesity in African Americans may identify novel pathways for regulation of adiposity, which is a strong predictor for many complex diseases including cardiometabolic diseases and cancer, etc. These goals will be met by performing the following specific aims. 1. Carry out a comprehensive analysis of the GWAS data. 2. Perform meta analysis of GWAS data from the Wake Forest University School of Medicine (WFUSM) Study, the Candidate Gene Association Resource (CARe) Study and the Health Aging and Body Composition (Health ABC) Study consisting of up to 11000 samples. 3. Genotype high scoring SNPs from Aims 1 and 2, as well as confirm loci from European GWAS studies in 6000 samples. 4. Follow up loci with strong evidence of association with BMI in African Americans for intensive bioinformatics and sequencing analyses to gain insights on their roles in adiposity regulation and association with cardiometabolic diseases. Successful completion of these aims will set the stage for future studies on the mechanisms of action of these loci at molecular, cellular, and organism levels to contribute to the long term goal on the prediction, prevention, and treatment of obesity in African Americans.

Public Health Relevance

This study is focused on identifying genes that ontribute to adiposity in the African American population.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK087914-03
Application #
8277959
Study Section
Kidney, Nutrition, Obesity and Diabetes (KNOD)
Program Officer
Karp, Robert W
Project Start
2010-06-21
Project End
2015-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
3
Fiscal Year
2012
Total Cost
$570,910
Indirect Cost
$185,160
Name
Wake Forest University Health Sciences
Department
Pediatrics
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Monda, Keri L; Chen, Gary K; Taylor, Kira C et al. (2013) A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet 45:690-6
Ng, Maggie C Y; Hester, Jessica M; Wing, Maria R et al. (2012) Genome-wide association of BMI in African Americans. Obesity (Silver Spring) 20:622-7
Hester, J M; Wing, M R; Li, J et al. (2012) Implication of European-derived adiposity loci in African Americans. Int J Obes (Lond) 36:465-73