NYU Langone Medical Center experienced an unprecedented storm on October 29th, 2012, causing damage that deeply impacted our patient care, research, and educational facilities. NYULMCs emergency power system was designed and built according to all safety codes to withstand a surge higher than the highest flood level for New York City in the past century. Superstorm Sandy obviously exceeded those levels. Although we safely evacuated over 300 patients from Tisch Hospital and Schwartz Health Care Center (HCC) in the midst of the storm, our main campus incurred extensive damage to its mechanical, electrical, and plumbing systems, requiring temporary closure of all buildings. There are three basic science buildings, the Skirball Institute, the Smilow Research Center, and the Medical Science Building (MSB). The below-ground levels of two of these buildings, the Smilow Research Center and MSB, which included two vivarium facilities, were significantly damaged. The upper research floors of the Smilow Research Center were re-opened in late December 2012, approximately two months after the Hurricane. However, the animal vivarium of Smilow was deemed completely unrecoverable, and the MSB vivarium remains closed.

Public Health Relevance

Patients with diabetes mellitus have a number of complications including cardiovascular disease (CVD) that might be secondary to changes in the biology of circulating white blood cells. We have created mouse models that show these changes and will isolate the effects of high glucose; as opposed to insulin signaling and lipid changes; on circulating blood cells and blood cells within arteries. Our studies will discover why diabetes leads to more cardiovascular disease and will identify targets to reduce the excess CVD in patients with diabetes.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Research Project (R01)
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Jones, Teresa L Z
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New York University
Internal Medicine/Medicine
Schools of Medicine
New York
United States
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Libby, Peter; Tabas, Ira; Fredman, Gabrielle et al. (2014) Inflammation and its resolution as determinants of acute coronary syndromes. Circ Res 114:1867-79
Nagareddy, Prabhakara R; Kraakman, Michael; Masters, Seth L et al. (2014) Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity. Cell Metab 19:821-35
Distel, Emilie; Barrett, Tessa J; Chung, Kellie et al. (2014) miR33 inhibition overcomes deleterious effects of diabetes mellitus on atherosclerosis plaque regression in mice. Circ Res 115:759-69
Nagareddy, Prabhakara R; Murphy, Andrew J; Stirzaker, Roslynn A et al. (2013) Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis. Cell Metab 17:695-708