Periodontal disease (gingivitis and periodontitis), prediabetes and type 2 diabetes mellitus (T2DM) are important public health problems as they are highly prevalent and their treatment is both difficult and expensive. Type 2 Diabetes (T2D) and periodontal disease are known to be strongly correlated. A large body of evidence suggests these correlations are causal and bidirectional. While diabetes is a generally well- accepted risk factor for the development of periodontal disease, classical bidirectional hypotheses only suggest periodontal disease to contribute to poor glycemic control among patients with established diabetes. However, in this proposal we hypothesize that dysbiotic subgingival microbial communities common in periodontal disease (i.e., periodontal infections) might contribute to insulin resistance and future development of prediabetes among initially diabetes-free individuals. Recent work by our group and others provides strong support for this hypothesis. Nevertheless, several limitations exist limiting causal inference and obscuring future research directions. First, temporality is unclear due to cross-sectional designs. Second, no study to date has comprehensively assessed the subgingival microbiome as it relates to prediabetes. Third, the potential role of inflammation as a mediator of associations between subgingival microbiota and prediabetes has not been examined in longitudinal studies. We will enroll and follow longitudinally 1,400 diabetes-free individuals to examine the co-evolution of the subgingival microbiome and the development of prediabetes. This will allow us to test hypotheses about the potentially bidirectional association between periodontal infection and impaired glucose regulation early in the natural history of both disease processes and well before the development of overt diabetes. This investigation will also generate important knowledge necessary for optimizing the design of future intervention studies. Specifically, future RCT designs will be optimized by knowledge about microbial community characteristics and inflammatory phenotypes associated with prediabetes risk, to ensure that susceptible individuals are enrolled and anti-infective treatment goals are achieved.

Public Health Relevance

We will longitudinally study interrelationships between the subgingival microbiome, systemic inflammation and impaired glucose regulation prior to the onset of diabetes. This will inform the temporality and biological plausibility of relationships between the subgingival microbiota and glucose regulation.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK102932-06
Application #
9696359
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Abraham, Kristin M
Project Start
2015-05-05
Project End
2021-04-30
Budget Start
2019-05-01
Budget End
2021-04-30
Support Year
6
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Crookes, Danielle M; Demmer, Ryan T; Keyes, Katherine M et al. (2018) Depressive Symptoms, Antidepressant Use, and Hypertension in Young Adulthood. Epidemiology 29:547-555
Demmer, Ryan T (2018) Invited Commentary: The Microbiome and Population Health-Considerations for Enhancing Study Design and Data Analysis in Observational and Interventional Epidemiology. Am J Epidemiol 187:1291-1294
Spinell, Thomas; DeMayo, Francesco; Cato, Matthew et al. (2018) The association between coeliac disease and periodontitis: Results from NHANES 2009-2012. J Clin Periodontol 45:303-310
Demmer, Ryan T; Breskin, Alexander; Rosenbaum, Michael et al. (2017) The subgingival microbiome, systemic inflammation and insulin resistance: The Oral Infections, Glucose Intolerance and Insulin Resistance Study. J Clin Periodontol 44:255-265
Demmer, Ryan T; Allison, Matthew A; Cai, Jianwen et al. (2016) Association of Impaired Glucose Regulation and Insulin Resistance With Cardiac Structure and Function: Results From ECHO-SOL (Echocardiographic Study of Latinos). Circ Cardiovasc Imaging 9:
Goh, Charlene E; Kopp, Jacob; Papapanou, Panos N et al. (2016) Association Between Serum Antibodies to Periodontal Bacteria and Rheumatoid Factor in the Third National Health and Nutrition Examination Survey. Arthritis Rheumatol 68:2384-93
Demmer, R T; Jacobs Jr, D R; Singh, R et al. (2015) Periodontal Bacteria and Prediabetes Prevalence in ORIGINS: The Oral Infections, Glucose Intolerance, and Insulin Resistance Study. J Dent Res 94:201S-11S