The broad, long-term objective of this work is to develop novel, time-efficient methods for MR data acquisition and corresponding real-time signal processing techniques to allow formation of MR images which portray the cardiovascular system with high spatial resolution. This is significant due to the high incidence of cardiovascular disease.
Specific aims to be studied in this work are: 1. Modified Elliptical Centric (EC) Acquisition Techniques. The EC view order will be combined with projection reconstruction (PR) k-space sampling to exploit the intrinsic advantages of both approaches. Variants of the EC-PR technique will be developed to provide: (i) improved resolution for given time using 2D homodyne (HD) reconstruction; (ii)time-resolved studies with frame rates as high as 2 Hz; (iii) compatibility with parallel imaging methods such as as SENSE for four-fold reduction in scan time; and (iv)compatibility with a combination of SENSE and HD reconstruction for six-fold scan time reduction for given resolution. The new methods will be applied to contrast-enhanced as well as non-contrast-enhanced MRA studies. 2. Real-Time Bolus Detection and Tracking. Means will be developed to detect and track contrast bolus transit in real time in a totally automated way as it moves through the vasculature over an extended field of view. This information will allow the generation of patient-specific bolus velocity profiles which can guide the MR angiographic pulse sequence and control table velocity and optimize spatial resolution on a patient- specific basis. 3. The Comprehensive Neurovascular Examination. The new acquisition and real-time computation techniques of Aims 1 and 2 will be integrated to provide a comprehensive angiogram of the aortic arch and great vessels, the carotid bifurcations, the intracranial arteries, and the draining veins of the brain following a single injection of contrast. Modest table motion during the exam will permit imaging of the extended FOV.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
5R01EB000212-22
Application #
7404384
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Program Officer
Liu, Guoying
Project Start
1984-08-01
Project End
2010-03-31
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
22
Fiscal Year
2008
Total Cost
$372,645
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
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Weavers, Paul T; Borisch, Eric A; Riederer, Stephen J (2015) Selection and evaluation of optimal two-dimensional CAIPIRINHA kernels applied to time-resolved three-dimensional CE-MRA. Magn Reson Med 73:2234-42
Stinson, Eric G; Trzasko, Joshua D; Weavers, Paul T et al. (2015) Dixon-type and subtraction-type contrast-enhanced magnetic resonance angiography: A theoretical and experimental comparison of SNR and CNR. Magn Reson Med 74:81-92
Weavers, Paul T; Borisch, Eric A; Johnson, Casey P et al. (2014) Acceleration apportionment: a method of improved 2D SENSE acceleration applied to 3D contrast-enhanced MR angiography. Magn Reson Med 71:672-80

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