Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
5R01EB000343-03
Application #
6682879
Study Section
Special Emphasis Panel (ZRG1-DMG (30))
Program Officer
Haller, John W
Project Start
2001-04-02
Project End
2006-03-31
Budget Start
2003-04-01
Budget End
2004-03-31
Support Year
3
Fiscal Year
2003
Total Cost
$204,525
Indirect Cost
Name
University of Arizona
Department
Type
Organized Research Units
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Deutsch, Gail; Muralidhar, Akshay; Le, Ellen et al. (2016) Extensive macrophage accumulation in young and old Niemann-Pick C1 model mice involves the alternative, M2, activation pathway and inhibition of macrophage apoptosis. Gene 578:242-50
Yoshimaru, Eriko; Totenhagen, John; Alexander, Gene E et al. (2014) Design, manufacture, and analysis of customized phantoms for enhanced quality control in small animal MRI systems. Magn Reson Med 71:880-4
Erickson, Robert P (2013) Current controversies in Niemann-Pick C1 disease: steroids or gangliosides; neurons or neurons and glia. J Appl Genet 54:215-24
Totenhagen, John W; Yoshimaru, Eriko S; Erickson, Robert P et al. (2013) (1) H magnetic resonance spectroscopy of neurodegeneration in a mouse model of niemann-pick type C1 disease. J Magn Reson Imaging 37:1195-201
Totenhagen, John W; Lope-Piedrafita, Silvia; Borbon, Ivan A et al. (2012) In vivo assessment of neurodegeneration in Niemann-Pick type C mice by quantitative T2 mapping and diffusion tensor imaging. J Magn Reson Imaging 35:528-36
Borbon, Ivan A; Hillman, Zach; Duran Jr, Ernesto et al. (2012) Lack of efficacy of curcumin on neurodegeneration in the mouse model of Niemann-Pick C1. Pharmacol Biochem Behav 101:125-31
Borbon, Ivan; Campbell, Erin; Ke, Wangjing et al. (2012) The role of decreased levels of Niemann-Pick C1 intracellular cholesterol transport on obesity is reversed in the C57BL/6J, metabolic syndrome mouse strain: a metabolic or an inflammatory effect? J Appl Genet 53:323-30
Jelinek, David A; Maghsoodi, Bita; Borbon, Ivan A et al. (2012) Genetic variation in the mouse model of Niemann Pick C1 affects female, as well as male, adiposity, and hepatic bile transporters but has indeterminate effects on caveolae. Gene 491:128-34
Borbon, Ivan; Totenhagen, John; Fiorenza, Maria Teresa et al. (2012) Niemann-Pick C1 mice, a model of ""juvenile Alzheimer's disease"", with normal gene expression in neurons and fibrillary astrocytes show long term survival and delayed neurodegeneration. J Alzheimers Dis 30:875-87
Borbon, Ivan A; Erickson, Robert P (2011) Interactions of Npc1 and amyloid accumulation/deposition in the APP/PS1 mouse model of Alzheimer's. J Appl Genet 52:213-8

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