In recent years we have successfully developed many methods to overcome problems associated with static and radiofrequency (RF) magnetic field distortions inherent with high field human MRI, but many challenges still remain. For this renewal we propose to 1) determine optimal configurations of practical transmit RF arrays and pulsing methods for safe, versatile, homogeneous RF excitation in the head and body at several key field strengths, 2) develop a reliable, real-time method of ensuring RF safety in transmit arrays, where currently an infinite number of power absorption patterns are possible for a given array and subject and little is known about the safety implications, and 3) implement and demonstrate key progressive transmit arrays and pulsing methods for body and head imaging at a few key field strengths, along with a reliable RF array safety monitoring system. To accomplish these Aims we will continue the partnership between the Pennsylvania State University (PSU: Lead Investigator CM Collins), the University of Minnesota (UMN: Lead Investigators K Ugurbil and JT Vaughan), and Remcom, Inc. (Lead Investigator R Luebbers). The partnership will be led by PSU. The approach will be multidisciplinary in that it will require 1) numerical simulations of a) RF fields (PSU, Remcom) b) nuclear magnetic phenomena (PSU), and c) temperature and related physiology (PSU, Remcom) to guide development of RF hardware and pulses and the safety monitoring system, 2) RF hardware design and implementation (PSU, UMN), and 3) high field MRI experiments (PSU, UMN). With this project we will make significant improvements to Magnetic Resonance Imaging (MRI) Technology. We will develop, implement, and demonstrate technology to make MRI safer, faster, and more effective for all research and, eventually, medical applications.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
5R01EB000454-11
Application #
8243466
Study Section
Special Emphasis Panel (ZRG1-SBIB-V (50))
Program Officer
Liu, Guoying
Project Start
2002-09-30
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2014-03-31
Support Year
11
Fiscal Year
2012
Total Cost
$1,001,091
Indirect Cost
$251,232
Name
New York University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Cao, Zhipeng; Park, Joshua; Cho, Zang-Hee et al. (2015) Numerical evaluation of image homogeneity, signal-to-noise ratio, and specific absorption rate for human brain imaging at 1.5, 3, 7, 10.5, and 14T in an 8-channel transmit/receive array. J Magn Reson Imaging 41:1432-9
Cao, Zhipeng; Oh, Sukhoon; Otazo, Ricardo et al. (2015) Complex difference constrained compressed sensing reconstruction for accelerated PRF thermometry with application to MRI-induced RF heating. Magn Reson Med 73:1420-31
Oh, Sukhoon; Ryu, Yeun-Chul; Carluccio, Giuseppe et al. (2014) Measurement of SAR-induced temperature increase in a phantom and in vivo with comparison to numerical simulation. Magn Reson Med 71:1923-31
Cao, Zhipeng; Oh, Sukhoon; Sica, Christopher T et al. (2014) Bloch-based MRI system simulator considering realistic electromagnetic fields for calculation of signal, noise, and specific absorption rate. Magn Reson Med 72:237-47
Carluccio, Giuseppe; Collins, Christopher M; Erricolo, Danilo (2014) A fast, analytically based method to optimize local transmit efficiency for a transmit array. Magn Reson Med 71:432-9
Liu, Wanzhan; Kao, Chien-ping; Collins, Christopher M et al. (2013) On consideration of radiated power in RF field simulations for MRI. Magn Reson Med 69:290-4
Carluccio, Giuseppe; Erricolo, Danilo; Oh, Sukhoon et al. (2013) An approach to rapid calculation of temperature change in tissue using spatial filters to approximate effects of thermal conduction. IEEE Trans Biomed Eng 60:1735-41
Wang, Jianli; Shaffer, Michele L; Eslinger, Paul J et al. (2012) Maturational and aging effects on human brain apparent transverse relaxation. PLoS One 7:e31907
Collins, Christopher M; Wang, Zhangwei (2011) Calculation of radiofrequency electromagnetic fields and their effects in MRI of human subjects. Magn Reson Med 65:1470-82
Yang, Qing X; Wang, Jianli; Wang, Jinghua et al. (2011) Reducing SAR and enhancing cerebral signal-to-noise ratio with high permittivity padding at 3 T. Magn Reson Med 65:358-62

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