We propose to develop shape memory polymer (SMP) interventional devices for treating stroke victims that currently have limited therapeutic alternatives (450,000/yr in the USA). The development and testing of two complementary devices is proposed: a foam for filling aneurysms and a mechanical clot extraction system. The foam will address a major cause of hemorrhagic strokes. The clot extraction system will address the current clinical need for an acute ischemic stroke treatment and is a second generation device based on the results from our initial funding period. The foundation of this proposal is the multidisciplinary team and the existing partnership that exists between the Medical Technology Program at LLNL and UC Davis Medical Center (UCD). The team is comprised of the four co-Pis: Duncan Maitland (LLNL), Thomas Wilson (LLNL), Judy Van de Water (UCD) and Jonathan Hartman (UCD). During our first four years of the initial BRP award we have demonstrated significant results that strengthen our original hypothesis that these relatively new materials will make possible novel and clinically feasible mechanical devices for treating/preventing stroke. Key developments during the first award period are the enabling cornerstones of the current proposal: novel SMP polyurethanes with improved thermomechanical, optical and biocompatibility properties;SMP foams;successful animal model and biocompatibility studies;multi-stage 3D fabrication techniques;and a large body of analytical, experimental and computational tools brought to bear on material properties and device-body interactions. At the end of a second five-year term of support we will be in a position to pursue commercial support for transferring the devices/technology to industry and, through this process, into the clinic.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
5R01EB000462-10
Application #
8265897
Study Section
Special Emphasis Panel (ZRG1-BDCN-E (10))
Program Officer
Hunziker, Rosemarie
Project Start
2002-05-03
Project End
2014-02-28
Budget Start
2012-03-01
Budget End
2014-02-28
Support Year
10
Fiscal Year
2012
Total Cost
$1,048,546
Indirect Cost
$180,116
Name
Texas Engineering Experiment Station
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
847205572
City
College Station
State
TX
Country
United States
Zip Code
77845
Hasan, S M; Thompson, R S; Emery, H et al. (2016) Modification of Shape Memory Polymer Foams Using Tungsten, Aluminum Oxide, and Silicon Dioxide Nanoparticles. RSC Adv 6:918-927
Im, Hyungsoon; Park, Yong Il; Pathania, Divya et al. (2016) Digital diffraction detection of protein markers for avian influenza. Lab Chip 16:1340-5
Boyle, Anthony J; Landsman, Todd L; Wierzbicki, Mark A et al. (2016) In vitro and in vivo evaluation of a shape memory polymer foam-over-wire embolization device delivered in saccular aneurysm models. J Biomed Mater Res B Appl Biomater 104:1407-15
Yu, Ya-Jen; Infanger, Stephen; Grunlan, Melissa A et al. (2015) Silicone Membranes to Inhibit Water Uptake into Thermoset Polyurethane Shape-Memory Polymer Conductive Composites. J Appl Polym Sci 132:
Hearon, Keith; Wierzbicki, Mark A; Nash, Landon D et al. (2015) A Processable Shape Memory Polymer System for Biomedical Applications. Adv Healthc Mater 4:1386-98
Rodriguez, Jennifer N; Hwang, Wonjun; Horn, John et al. (2015) Design and biocompatibility of endovascular aneurysm filling devices. J Biomed Mater Res A 103:1577-94
Im, Hyungsoon; Castro, Cesar M; Shao, Huilin et al. (2015) Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone. Proc Natl Acad Sci U S A 112:5613-8
Rodriguez, Jennifer N; Miller, Matthew W; Boyle, Anthony et al. (2014) Reticulation of low density shape memory polymer foam with an in vivo demonstration of vascular occlusion. J Mech Behav Biomed Mater 40:102-14
Hearon, Keith; Nash, Landon D; Rodriguez, Jennifer N et al. (2014) A high-performance recycling solution for polystyrene achieved by the synthesis of renewable poly(thioether) networks derived from D-limonene. Adv Mater 26:1552-8
Rodriguez, Jennifer N; Clubb, Fred J; Wilson, Thomas S et al. (2014) In vivo response to an implanted shape memory polyurethane foam in a porcine aneurysm model. J Biomed Mater Res A 102:1231-42

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